182126-75-6Relevant academic research and scientific papers
Synthesis of purine and pyrimidine 3′-amino-3′-deoxy- and 3′-amino-2′,3′-dideoxyxylonucleosides
Garcia-Alles, Luis F.,Magdalena, Julia,Gotor, Vicente
, p. 6980 - 6986 (2007/10/03)
A general procedure to obtain the 3′-aminoxylonucleosides 13a,b and 17a,b is presented. The synthetic scheme is based on the 5′ directed intramolecular nucleophilic substitution at the 3′-activated position of the nucleoside. The approach of the incoming group to this position takes place regio- and stereoselectively from the most hindered face of the nucleoside. The methodology presented is applicable to ribonucleosides and 2′-deoxyribonucleosides, regardless of their nitrogenated base.
