182181-19-7

Usage

Uses

Used in Pharmaceutical Industry:
6-CHLOROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID is used as a key building block for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, potentially leading to the discovery of novel treatments for a wide range of diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 6-CHLOROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID is utilized as a starting material for the synthesis of various agrochemicals. Its properties make it suitable for the development of new pesticides, herbicides, and other agricultural chemicals, contributing to more effective and sustainable agricultural practices.
Used in Medicinal Chemistry Research:
6-CHLOROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID is employed as a research tool in medicinal chemistry. Its unique structure and reactivity enable scientists to explore its potential in the development of new drug candidates, leading to advancements in the understanding of disease mechanisms and the discovery of innovative therapeutic approaches.
Used in Chemical Biology and Bioorganic Chemistry:
As a research tool in chemical biology and bioorganic chemistry, 6-CHLOROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID is used to study the interactions between small molecules and biological systems. Its unique properties allow researchers to investigate its potential as a modulator of biological processes, providing insights into the development of new therapeutic agents and the understanding of complex biological systems.

InChI:InChI=1/C8H5ClN2O2/c9-5-1-2-7-10-6(8(12)13)4-11(7)3-5/h1-4H,(H,12,13)/p-1

Upstream product

• 1600507-33-2 (3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide 
• 1600506-36-2 (3R,6R)-5-Amino-3-(5-bromo-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide 
• 1600511-35-0 tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)thio)propan-2-yl)carbamate 
• 1600511-33-8 (R)-S-(2-(5-Bromo-2-fluorophenyl)-2-((tert-butoxy carbonyl)amino)propyl) ethanethioate 
• 1600511-48-5 tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate 
• 1072-98-6 5-chloro-2-pyridylamine 
• 1113-59-3 bromopyruvic acid 
• 67625-38-1 6-chloroimidazo[1,2-a]pyridine-2-carboxylate 

Relevant academic research and scientific papers

AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles

[Chemical equation presented] The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.

IMIDAZO[1,2-A]PYRIDINES FOR THE TREATMENT OF CNS AND CARDIAC DISEASES

The present invention relates to imidazo[1,2-a]pyridine compounds of formula (1) STR1 which are dopamine D-4 antagonists and useful as anti-psychotic agents.