182181-25-5

Basic information

• Product Name: 6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE
• Synonyms: 6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE;IMidazo[1,2-a]pyridine, 6-chloro-2-(chloroMethyl)-
• CAS NO: 182181-25-5
• Molecular Formula: C₈H₆Cl₂N₂
• Molecular Weight: 201.05
• Mol File: 182181-25-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.45g/cm³
• Refractive Index: 1.65
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE(182181-25-5)
• EPA Substance Registry System: 6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE(182181-25-5)

Safety Data

• Hazardous Substances Data: 182181-25-5(Hazardous Substances Data)

Usage

General Description

6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE is a chemical compound with the molecular formula C8H5Cl2N3. It is a chloro-substituted imidazopyridine derivative, which is commonly used in the pharmaceutical industry for the synthesis of various drugs and agrochemicals. 6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE is known for its potent biological activities and is often used as a building block in the development of new therapeutic agents. It exhibits significant antibacterial, antifungal, and antiparasitic properties, making it a valuable chemical in drug discovery and development. Additionally, 6-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE is also used in the synthesis of various specialty chemicals and is a versatile building block in organic synthesis.

InChI:InChI=1/C8H6Cl2N2/c9-3-7-5-12-4-6(10)1-2-8(12)11-7/h1-2,4-5H,3H2

Upstream product

• 1039416-36-8 6-chloroimidazo[1,2-a]pyridine-2-yl-methanol 
• 1072-98-6 5-chloro-2-pyridylamine 
• 534-07-6 1,3-Dichloroacetone 

Downstream Products

• 182181-02-8 6-Chloro-2-[[4-(3-chloro4-methoxyphenyl)-1-piperazinyl]-methyl]imidazo[1,2-a]pyridine 
• 182180-77-4 3-chloro-4-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]benzonitrile 
• 1059044-59-5 6-chloro-3-nitro-2-(tosylmethyl)imidazo[1,2-a]pyridine 
• 478394-28-4 2-benzenesulfonylmethyl-6-chloroimidazo[1,2-a]pyridine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF AMYLOID-RELATED DISEASES

A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

Targeting the human parasite Leishmania donovani: Discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series

We report herein the discovery of antileishmanial molecules based on the imidazo[1,2-a]pyridine ring. In vitro screenings of imidazopyridines belonging to our chemical library, toward the promastigotes stage of Leishmania donovani, J774A.1 murine and HepG2 human cells, permitted to identify three selective hit-compounds (12, 20 and 28). New derivatives were then synthesized to allow structure-activity and -toxicity relationships analyses, enabling to characterize a lead-compound (44) displaying both a high potency (IC 50 = 1.8 μM) and a good selectivity index, in comparison with three antileishmanial reference drug-compounds (amphotericin B, miltefosine and pentamidine). Moreover, lead-compound 44 also exhibits good in vitro activity against the intracellular amastigote stage of L. donovani. Thus, the 6-halo-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridine scaffold appears as a new promising selective antileishmanial pharmacophore, especially when substituted at position 8 by a bromine atom.

IMIDAZO[1,2-A]PYRIDINES FOR THE TREATMENT OF CNS AND CARDIAC DISEASES

The present invention relates to imidazo[1,2-a]pyridine compounds of formula (1) STR1 which are dopamine D-4 antagonists and useful as anti-psychotic agents.