182198-89-6

Basic information

• Product Name: 5-PHENYL-THIENO[2,3-D]PYRIMIDINE-4-THIOL
• Synonyms: THIENO[2,3-D]PYRIMIDINE-4-THIOL, 5-PHENYL-;5-PHENYL-THIENO[2,3-D]PYRIMIDINE-4-THIOL
• CAS NO: 182198-89-6
• Molecular Formula: C₁₂H₈N₂S₂
• Molecular Weight: 244.34
• Mol File: 182198-89-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 445.4 °C at 760 mmHg
• Flash Point: 223.2 °C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.04E-07mmHg at 25°C
• CAS DataBase Reference: 5-PHENYL-THIENO[2,3-D]PYRIMIDINE-4-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-THIENO[2,3-D]PYRIMIDINE-4-THIOL(182198-89-6)
• EPA Substance Registry System: 5-PHENYL-THIENO[2,3-D]PYRIMIDINE-4-THIOL(182198-89-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 182198-89-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8N2S2/c15-11-10-9(8-4-2-1-3-5-8)6-16-12(10)14-7-13-11/h1-7H,(H,13,14,15)/p-1

Upstream product

• 35978-39-3 5-phenylthieno<2,3-d>pyrimidine-4(3H)one 
• 98-86-2 acetophenone 
• 4815-36-5 ethyl 2-amino-4-phenyl-thiophene-3-carboxylate 
• 182198-35-2 4-chloro-5-phenyl-thieno[2,3-d]pyrimidine 

Downstream Products

• 457642-12-5 C₁₇H₁₆N₂O₂S₂ 
• 446831-04-5 2-[(5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]propanoic acid 
• 312947-24-3 [(5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2

A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the most active compounds inhibiting CK2 are 3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid and 3-{[5-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid (IC 50 values are 0.1 μM and 0.125 μM, respectively). Structure-activity relationships of 28 tested thienopyrimidine derivatives have been studied and binding mode of this chemical class has been predicted. Evaluation of the inhibitors on seven protein kinases revealed considerable selectivity towards CK2.