312947-24-3 Usage
General Description
[(5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid is a chemical compound with a molecular formula C16H11N3O2S2. It belongs to the thienopyrimidine class of compounds and contains a phenyl group and a thioacetic acid moiety. [(5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid is often used in medicinal chemistry research and drug development due to its potential biological activity. It is believed to have therapeutic potential in the treatment of various diseases, including cancer and inflammation. The synthesis and study of [(5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid are important in the discovery and development of new pharmaceuticals and biologically active compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 312947-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,2,9,4 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 312947-24:
(8*3)+(7*1)+(6*2)+(5*9)+(4*4)+(3*7)+(2*2)+(1*4)=133
133 % 10 = 3
So 312947-24-3 is a valid CAS Registry Number.
312947-24-3Relevant articles and documents
Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2
Golub, Andriy G.,Bdzhola, Volodymyr G.,Briukhovetska, Nadiia V.,Balanda, Anatoliy O.,Kukharenko, Olexander P.,Kotey, Igor M.,Ostrynska, Olga V.,Yarmoluk, Sergiy M.
, p. 870 - 876 (2011/04/22)
A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the most active compounds inhibiting CK2 are 3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid and 3-{[5-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid (IC 50 values are 0.1 μM and 0.125 μM, respectively). Structure-activity relationships of 28 tested thienopyrimidine derivatives have been studied and binding mode of this chemical class has been predicted. Evaluation of the inhibitors on seven protein kinases revealed considerable selectivity towards CK2.
