182223-09-2Relevant academic research and scientific papers
Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazolone derivatives
Schaus, John M.,Thompson, Dennis C.,Bloomquist, William E.,Susemichel, Alice D.,Calligaro, David O.,Cohen, Marlene L.
, p. 1943 - 1955 (1998)
A series of indole-3-carboxamides, indazole-3-carboxamides, and benzimidazolone-3-carboxamides was synthesized and evaluated for antagonist affinity at the 5-HT4 receptor in the rat esophagus. The endo-3-tropanamine derivatives in the indazole
Indazole derivatives having monocyclic amine
-
, (2008/06/13)
An indazole compound having the formula (I): wherein: R1 is hydrogen, C1 -C6 alkyl, C3 -C6 alkenyl or C3 -C6 cycloalkyl; Q is carbonyl, thiocarbonyl or methylene; and R2 is a group of the formula (II) or (IV); STR1 wherein R1 is C1 -C6 alkyl, C3 -C6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT4 receptor agonist activity.
Indazolecarboxamides
-
, (2008/06/13)
Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT 4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT 4 receptor.
