Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazolone derivatives

DOI: 10.1021/jm970857f

Source and publish data:

Journal of Medicinal Chemistry p. 1943 - 1955 (1998)

Update date:2022-08-03

Topics:

Authors:

Schaus, John M.

Thompson, Dennis C.

Bloomquist, William E.

Susemichel, Alice D.

Calligaro, David O.

Cohen, Marlene L.

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Article abstract of DOI:10.1021/jm970857f

A series of indole-3-carboxamides, indazole-3-carboxamides, and benzimidazolone-3-carboxamides was synthesized and evaluated for antagonist affinity at the 5-HT₄ receptor in the rat esophagus. The endo-3-tropanamine derivatives in the indazole

Full text of DOI:10.1021/jm970857f

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Product name:1H-Indazole-3-carboxamide, N-[2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-

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