18226-16-9

Basic information

• Product Name: 2-(Methyl(4-nitrophenyl)aMino)ethanol
• Synonyms: 2-(Methyl(4-nitrophenyl)aMino)ethanol;N-(2-HYDROXYETHYL)-N-METHYL-4-NITROANILINE
• CAS NO: 18226-16-9
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.20318
• Mol File: 18226-16-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Methyl(4-nitrophenyl)aMino)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methyl(4-nitrophenyl)aMino)ethanol(18226-16-9)
• EPA Substance Registry System: 2-(Methyl(4-nitrophenyl)aMino)ethanol(18226-16-9)

Safety Data

• Hazardous Substances Data: 18226-16-9(Hazardous Substances Data)

Usage

General Description

2-(Methyl(4-nitrophenyl)aMino)ethanol is a chemical compound with the molecular formula C9H12N2O3. It is a derivative of ethanol and contains a methyl group, a nitrophenyl group, and an amino group. 2-(Methyl(4-nitrophenyl)aMino)ethanol has potential applications in pharmaceuticals as a building block for the synthesis of various drugs. It is also used as a reagent in chemical synthesis and as a substrate in biochemical studies. 2-(Methyl(4-nitrophenyl)aMino)ethanol is a versatile and important chemical with diverse potential uses in various industries.

Upstream product

• 60814-17-7 N-methyl-2-(p-nitrophenoxy)ethylamine 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 350-46-9 4-Fluoronitrobenzene 
• 586-78-7 para-nitrophenyl bromide 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 18226-06-7 N-(2-hydroxyethyl)-N-methyl-4-nitro-benzenesulfonamide 

Relevant articles and documents

PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF

The present invention discloses a pyrimidine compound, a preparation method thereof and a medical use thereof. Specifically, the present invention discloses a pyrimidine compound represented by formula (I), pharmaceutically acceptable salts thereof, a preparation method thereof, and a use thereof as a cyclin-dependent kinase 9 (CDK9) inhibitor, particularly for the treatment of cancer. The definition of each group in formula (I) is the same as that in the specification.

A Direct C-H/Ar-H Coupling Approach to Oxindoles, Thio-oxindoles, 3,4-Dihydro-1 H-quinolin-2-ones, and 1,2,3,4-Tetrahydroquinolines

A copper(II)-catalysed approach to oxindoles, thio-oxindoles, 3,4-dihydro-1H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines via formal C-H, Ar-H coupling is described. In a new variant, copper(II) 2-ethylhexanoate has been identified as an inexpensive and efficient catalyst for this transformation, which utilises atmospheric oxygen as the re-oxidant. Copper(II) 2-ethylhexanoate: The synthesis of oxindoles, thio-oxindoles, 3,4-dihydro-1H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines from linear precursors by direct C-H, Ar-H coupling by using a single copper catalyst is reported (see scheme; DIPEA=diisopropylethylamine, EWG=electron-withdrawing group). The cyclisations are simple to perform, run open to the air, are moisture insensitive, and use an inexpensive catalyst.

4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS

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