18226-19-2Relevant academic research and scientific papers
Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement
Yang, Di,Xie, Cai-Xia,Wu, Xiao-Tian,Fei, Luo-Ran,Feng, Lei,Ma, Chen
, p. 14905 - 14915 (2020/11/13)
A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.
Synthesis of benzannulated N-heterocycles by a palladium-catalyzed C-C/C-N coupling of bromoalkylamines
Thansandote, Praew,Raemy, Manuel,Rudolph, Alena,Lautens, Mark
, p. 5255 - 5258 (2008/09/17)
(Chemical Equation Presented) A palladium-catalyzed domino intermolecular alkylation/intramolecular amination of functionalized aryl iodides represents a new strategy for the synthesis of benzannulated N-heterocycles, affording functionalized indolines an
