18227-67-3

Basic information

• Product Name: 4-Pyridinamine, 3-methyl-5-nitro-
• Synonyms: 4-Pyridinamine, 3-methyl-5-nitro-;4-Amino-5-methyl-3-nitropyridine;4-AMino-3-Methyl-5-nitropyridine;3-Methyl-5-nitropyridin-4-aMine;3-Methyl-5-nitro-4-pyridinamine
• CAS NO: 18227-67-3
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Mol File: 18227-67-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 193 °C(Solv: water (7732-18-5))
• Boiling Point: 362.7 °C at 760 mmHg
• Flash Point: 173.2 °C
• Appearance: /
• Density: 1.354 g/cm³
• Vapor Pressure: 1.89E-05mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.25±0.24(Predicted)
• CAS DataBase Reference: 4-Pyridinamine, 3-methyl-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinamine, 3-methyl-5-nitro-(18227-67-3)
• EPA Substance Registry System: 4-Pyridinamine, 3-methyl-5-nitro-(18227-67-3)

Safety Data

• Hazardous Substances Data: 18227-67-3(Hazardous Substances Data)

Usage

General Description

4-Pyridinamine, 3-methyl-5-nitro- is a chemical compound with the molecular formula C6H7N3O2. It is a derivative of pyridine with a nitro and methyl group attached to the 3 and 5 positions, respectively. 4-Pyridinamine, 3-methyl-5-nitro- has a yellow color and is used in organic synthesis and chemical research. It is often utilized as a building block in the production of pharmaceuticals and agrochemicals. Additionally, 4-Pyridinamine, 3-methyl-5-nitro- has potential applications in the field of material science and as a reagent in various chemical reactions.

InChI:InChI=1/C6H7N3O2/c1-4-2-8-3-5(6(4)7)9(10)11/h2-3H,1H3,(H2,7,8)

Upstream product

• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1990-90-5 4-amino-3-methylpyridine 
• 1003-73-2 3-picoline-N-oxide 
• 18227-66-2 4-nitramino-3-methylpyridine 

Downstream Products

• 13958-86-6 5-methyl-3,4-pyridinediamine 
• 18232-91-2 4,5-diamino-6-chloro-3-methylpyridine 
• 515815-10-8 2'-deoxy-3',5'-di-O-p-toluoyl-4-chloro-7-methyl-1-β-D-ribofuranosyl-1(H)-imidazo[4,5-c]pyridine 
• 515815-09-5 2'-deoxy-3',5'-di-O-p-toluoyl-7-chloro-4-methyl-1-β-D-ribofuranosyl-3(H)-imidazo[4,5-c]pyridine 

Relevant articles and documents

A model D - amino acid oxidase inhibitor and its preparation and application

The invention provides a novel D- amino acid oxidase inhibitor and a preparation and application thereof. In particular, the invention discloses derivatives of quinoxaline-2,3-diketone, which has a novel structure shown in formula A, as well as a preparation method thereof and an application as an inhibitor of D-amino acid oxidase (DAAO). The compound provided by the invention shows excellent effects of analgesia and blocking morphine analgesia tolerance, and has application value for analgesia, treating opiate drug tolerance, and anti-schizophrenia.

The synthesis of anti-fixed 3-methyl-3-deaza-2′-deoxyadenosine and other 3h-imidazo[4,5-c]pyridine analogs

Rotation of a heterocyclic base around a glycosidic bond allows the formation of syn and anti conformations in nucleosides. The syn conformation has been observed primarily in purine-purine mismatches in DNA duplexes. Such mismatches give rise to false positive oligonucleotide hybridization in DNA-based diagnostics. Here we describe the synthesis of an analog of 2′-deoxyadenosine that retains its Watson-Crick functional groups, but cannot form the syn conformation. In this analog, the N3 atom of 2′-deoxyadenosine is replaced by a C-CH3 group to give 7-methyl-1-β-D-deoxyribofuranosyl-1H-imidazo[4,5-c]pyridin-4-ylamine or 3-methyl-3-deaza-2′-deoxyadenosine (3mddA). This modification sterically prevents the syn conformation and 3mddA becomes an anti-fixed nucleoside analog of 2′-deoxyadenosine. The synthesis and conformational analysis of 3mddA and several analogs with an 3H-imidazo[4,5-c]pyridine skeleton are described, as well as their potential applications.