18227-67-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Pyridinamine, 3-methyl-5-nitrois used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-Pyridinamine, 3-methyl-5-nitrois also utilized as a building block in the production of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Material Science:
4-Pyridinamine, 3-methyl-5-nitrohas potential applications in material science, where its unique chemical properties can be exploited to develop new materials with specific characteristics for various industrial applications.
Used as a Reagent in Chemical Reactions:
Due to its reactive functional groups, 4-Pyridinamine, 3-methyl-5-nitroserves as a versatile reagent in various chemical reactions, enabling the synthesis of a wide range of organic compounds for research and industrial purposes.

InChI:InChI=1/C6H7N3O2/c1-4-2-8-3-5(6(4)7)9(10)11/h2-3H,1H3,(H2,7,8)

Upstream product

• 18227-66-2 4-nitramino-3-methylpyridine 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1003-73-2 3-picoline-N-oxide 
• 1990-90-5 4-amino-3-methylpyridine 

Downstream Products

• 18232-91-2 4,5-diamino-6-chloro-3-methylpyridine 
• 13958-86-6 5-methyl-3,4-pyridinediamine 
• 515815-10-8 2'-deoxy-3',5'-di-O-p-toluoyl-4-chloro-7-methyl-1-β-D-ribofuranosyl-1(H)-imidazo[4,5-c]pyridine 
• 515815-09-5 2'-deoxy-3',5'-di-O-p-toluoyl-7-chloro-4-methyl-1-β-D-ribofuranosyl-3(H)-imidazo[4,5-c]pyridine 

Relevant academic research and scientific papers

A model D - amino acid oxidase inhibitor and its preparation and application

The invention provides a novel D- amino acid oxidase inhibitor and a preparation and application thereof. In particular, the invention discloses derivatives of quinoxaline-2,3-diketone, which has a novel structure shown in formula A, as well as a preparation method thereof and an application as an inhibitor of D-amino acid oxidase (DAAO). The compound provided by the invention shows excellent effects of analgesia and blocking morphine analgesia tolerance, and has application value for analgesia, treating opiate drug tolerance, and anti-schizophrenia.

IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT

The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

The synthesis of anti-fixed 3-methyl-3-deaza-2′-deoxyadenosine and other 3h-imidazo[4,5-c]pyridine analogs

Rotation of a heterocyclic base around a glycosidic bond allows the formation of syn and anti conformations in nucleosides. The syn conformation has been observed primarily in purine-purine mismatches in DNA duplexes. Such mismatches give rise to false positive oligonucleotide hybridization in DNA-based diagnostics. Here we describe the synthesis of an analog of 2′-deoxyadenosine that retains its Watson-Crick functional groups, but cannot form the syn conformation. In this analog, the N3 atom of 2′-deoxyadenosine is replaced by a C-CH3 group to give 7-methyl-1-β-D-deoxyribofuranosyl-1H-imidazo[4,5-c]pyridin-4-ylamine or 3-methyl-3-deaza-2′-deoxyadenosine (3mddA). This modification sterically prevents the syn conformation and 3mddA becomes an anti-fixed nucleoside analog of 2′-deoxyadenosine. The synthesis and conformational analysis of 3mddA and several analogs with an 3H-imidazo[4,5-c]pyridine skeleton are described, as well as their potential applications.