18232-91-2

Basic information

• Product Name: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-
• Synonyms: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-;2-Chloro-3,4-diamino-5-methylpyridine;2-Chloro-5-Methylpyridine-3,4-diaMine
• CAS NO: 18232-91-2
• Molecular Formula: C₆H₈ClN₃
• Molecular Weight: 157.6
• Mol File: 18232-91-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-(18232-91-2)
• EPA Substance Registry System: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-(18232-91-2)

Safety Data

• Hazardous Substances Data: 18232-91-2(Hazardous Substances Data)

Usage

Description

3-PICOLINE, 4,5-DIAMINO-6-CHLOROis a versatile chemical compound that features a 3-picolylamine moiety and a 4,5-diamino-6-chloropyrimidine moiety, covalently bonded with a hydrogen atom. It is recognized for its potential in various industries, particularly as an intermediate or raw material in the synthesis of pharmaceutical products, agrochemicals, and dyestuffs. Its unique properties make it a valuable component in the construction of diverse chemical structures and a promising candidate for the development of new drugs.

Uses

Used in Pharmaceutical Industry:
3-PICOLINE, 4,5-DIAMINO-6-CHLOROis used as a key intermediate for the synthesis of various pharmaceutical products. Its unique structure allows it to be a building block in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-PICOLINE, 4,5-DIAMINO-6-CHLOROis utilized as a raw material for the production of agrochemicals. Its chemical properties make it suitable for the formulation of effective and targeted agrochemical products.
Used in Dye Industry:
3-PICOLINE, 4,5-DIAMINO-6-CHLOROis employed as a component in the preparation of dyestuffs. Its chemical structure contributes to the creation of dyes with specific properties, enhancing the colorfastness and performance of the final products in various applications.

Upstream product

• 1003-73-2 3-picoline-N-oxide 
• 18227-66-2 4-nitramino-3-methylpyridine 
• 1990-90-5 4-amino-3-methylpyridine 
• 18227-67-3 4-amino-3-methyl-5-nitropyridine 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 

Downstream Products

• 1421597-90-1 C₃₃H₂₈N₈O 
• 1421597-89-8 C₃₃H₃₁N₇O 
• 515815-10-8 2'-deoxy-3',5'-di-O-p-toluoyl-4-chloro-7-methyl-1-β-D-ribofuranosyl-1(H)-imidazo[4,5-c]pyridine 
• 515815-09-5 2'-deoxy-3',5'-di-O-p-toluoyl-7-chloro-4-methyl-1-β-D-ribofuranosyl-3(H)-imidazo[4,5-c]pyridine 

Relevant articles and documents

The synthesis of anti-fixed 3-methyl-3-deaza-2′-deoxyadenosine and other 3h-imidazo[4,5-c]pyridine analogs

Rotation of a heterocyclic base around a glycosidic bond allows the formation of syn and anti conformations in nucleosides. The syn conformation has been observed primarily in purine-purine mismatches in DNA duplexes. Such mismatches give rise to false positive oligonucleotide hybridization in DNA-based diagnostics. Here we describe the synthesis of an analog of 2′-deoxyadenosine that retains its Watson-Crick functional groups, but cannot form the syn conformation. In this analog, the N3 atom of 2′-deoxyadenosine is replaced by a C-CH3 group to give 7-methyl-1-β-D-deoxyribofuranosyl-1H-imidazo[4,5-c]pyridin-4-ylamine or 3-methyl-3-deaza-2′-deoxyadenosine (3mddA). This modification sterically prevents the syn conformation and 3mddA becomes an anti-fixed nucleoside analog of 2′-deoxyadenosine. The synthesis and conformational analysis of 3mddA and several analogs with an 3H-imidazo[4,5-c]pyridine skeleton are described, as well as their potential applications.