182275-66-7

Upstream product

• 182275-65-6 3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-ol 
• 110299-41-7 2-[(5-methyl-2-phenyl-2H-pyrazol-3-ylamino)methylene]malonic acid diethyl ester 
• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 100-63-0 phenylhydrazine 
• 182275-64-5 4-Hydroxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 81153-42-6 4-Chloro-3-methyl-1-phenylpyrazolo<3,4-b>pyridine-5-carboxylic acid 
• 81153-44-8 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 

Downstream Products

• 182275-67-8 (3-Methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-hydrazine 

Relevant academic research and scientific papers

Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists

Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.

Synthesis and analgesic properties of new 4-arylhydrazone 1-H pyrazole [3,4-b]pyridine derivatives

Based on the principle of bioisosterism, a successful strategy in the planning of new drugs, we describe in this work the synthesis and the analgesic activity of the new functionalized arylcarbaldehyde 4-(1-phenyl-3-methylpyrazolo[3,4-b]pyridine] hydrazon