1823-25-2

Upstream product

• 94100-12-6 5-chloro-3-(2-methoxyphenyl)-2,1-benzisoxazole 
• 135-02-4 ortho-anisaldehyde 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 937058-18-9 tert-butyl 4-chloro-2-(2-methoxybenzoyl)phenylcarbamate 
• 635-21-2 5-chloroanthranilic acid 
• 7035-02-1 o-Methoxybenzyl chloride 
• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 612-16-8 (2-methoxyphenyl)methanol 
• 2894-64-6 2-Acetamino-4-chloro-2'-methoxybenzophenone 

Downstream Products

• 62492-57-3 2-Amino-4-chloro-2'-hydroxybenzophenone 
• 129687-77-0 2-Amino-4-chloro-2'-(cyanomethyloxy)benzophenone 
• 2890-32-6 7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione 
• 3023-44-7 7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 
• 115435-87-5 8-chloro-6-(2-methoxyphenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 115435-84-2 8-chloro-6-(2-methoxyphenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 152911-60-9 (2-amino-5-chloro-phenyl)-(2-methoxy-phenyl)-methanol 
• 115435-82-0 5-chloro-2'-methoxy-2-(phthalimidoacetamido)benzophenone 
• 152911-94-9 (E)-3-[{4-Chloro-2-[hydroxy-(2-methoxy-phenyl)-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester 
• 152911-72-3 {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}-(2-methoxyphenyl)methanol 

Relevant academic research and scientific papers

TRICYCLIC COMPOUND

The present invention relates to tricyclic compounds each represented by the following formula (I): (wherein, R1, R2, R2', R3, R4, X, Y and Z have the same meanings as defined in the specification); and a drug containing the compound. Since the compounds according to the present invention exhibit an excellent squalene synthetase inhibitory effect and cholesterol synthesis inhibitory effect so that they are useful as a drug such as preventive and/or remedy for diseases in mammals including humans such as hyperlipemia, e.g., hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia and/or arteriosclerosis.

TRICYCLIC BENZAZEPINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS USED FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

The invention relates to novel tricyclic benzazepine derivatives of formula (I), methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for the treatment and/or prophylaxis of diseases, preferably cardiovascular diseases, particularly dyslipidemia, arteriosclerosis, restenosis, and ischemia.

The Synthesis of Benzofuroquinolines. VIII. Some Halobenzofuroquinoline Derivatives

Three 2-halo-6(5H)-benzofuroquinolinones 1 (X = F, Cl, Br) were synthesized in two procedures, photocyclization of N-benzyl-N-(p-halophenyl)-2-benzofurancarboxamides 3 (X = F, Cl, Br) and condensation of 2-amino-2'-hydroxybenzophenones 7 (X = F, Cl

REACTION OF 4-CHLORO-1-NITROBENZENE WITH o-SUBSTITUTED PHENYLACETONITRILES; SYNTHESIS OF 8-CHLORO-1-METHYL(AND METHYLTHIOMETHYL)-6-(2-SUBSTITUTED PHENYL)-4H-s-TRIAZOLO-1,4-BENZODIAZEPINES

Reactions of 4-chloro-1-nitrobenzene with 2-methyl-, 2-methoxy- and 2-(methylthio)phenylacetonitrile in methanolic potassium hydroxide gave mixture from which the excepted 3-aryl-5-chloro-2,1-benzisoxazoles Ia-c were isolated in addition to the 2H-indoles IIIa and IIIc and acridines VIII and IX.The 2,1-benzisoxazoles were reduced to the 2-aminobenzophenones XIIa-c which were transformed via the phthalimidoacetamido compounds XIIIa-c to 5-aryl-7-chloro-1,3-dihydro-1,4-benzodiazepine-2-ones XVa-c.Treatment with phosphorus pentasulfide led to the thiones XVIa-c which reacted in boiling butanol either with acetohydrazide or with (methylthio)acetohydrazide to give the title compounds XVIIa-c and XVIIIa-c.They showed only weak anticonvulsant, incoordinating and central depressant effects.