115435-87-5

Basic information

• Product Name: 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether
• Synonyms: 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether
• CAS NO: 115435-87-5
• Molecular Formula: C₁₉H₁₇ClN₄OS
• Molecular Weight: 384.88248
• Mol File: 115435-87-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether(115435-87-5)
• EPA Substance Registry System: 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether(115435-87-5)

Safety Data

• Hazardous Substances Data: 115435-87-5(Hazardous Substances Data)

Upstream product

• 3023-44-7 7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 
• 1823-25-2 2-Amino-4-chloro-2'-methoxybenzophenone 
• 135-02-4 ortho-anisaldehyde 
• 7035-02-1 o-Methoxybenzyl chloride 
• 115435-82-0 5-chloro-2'-methoxy-2-(phthalimidoacetamido)benzophenone 
• 94100-12-6 5-chloro-3-(2-methoxyphenyl)-2,1-benzisoxazole 
• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 612-16-8 (2-methoxyphenyl)methanol 
• 74085-88-4 ethyl(methylthio)acetic hydrazide 
• 2890-32-6 7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione 

Relevant articles and documents

REACTION OF 4-CHLORO-1-NITROBENZENE WITH o-SUBSTITUTED PHENYLACETONITRILES; SYNTHESIS OF 8-CHLORO-1-METHYL(AND METHYLTHIOMETHYL)-6-(2-SUBSTITUTED PHENYL)-4H-s-TRIAZOLO-1,4-BENZODIAZEPINES

Reactions of 4-chloro-1-nitrobenzene with 2-methyl-, 2-methoxy- and 2-(methylthio)phenylacetonitrile in methanolic potassium hydroxide gave mixture from which the excepted 3-aryl-5-chloro-2,1-benzisoxazoles Ia-c were isolated in addition to the 2H-indoles IIIa and IIIc and acridines VIII and IX.The 2,1-benzisoxazoles were reduced to the 2-aminobenzophenones XIIa-c which were transformed via the phthalimidoacetamido compounds XIIIa-c to 5-aryl-7-chloro-1,3-dihydro-1,4-benzodiazepine-2-ones XVa-c.Treatment with phosphorus pentasulfide led to the thiones XVIa-c which reacted in boiling butanol either with acetohydrazide or with (methylthio)acetohydrazide to give the title compounds XVIIa-c and XVIIIa-c.They showed only weak anticonvulsant, incoordinating and central depressant effects.