945473-52-9

Upstream product

• 766513-83-1 C₄₂H₆₇N₅O₁₃ 
• 766513-79-5 (3S,4R)-4-(tert-butoxycarbonylamino)-5-methyl-3-(tert-butyldimethylsilanyloxy)hexanoic acid 
• 766513-78-4 (3S,4R)-4-(tert-butoxycarbonylamino)-5-methyl-3-(tert-butyldimethylsilanyloxy)hexanoic acid methyl ester 
• 387823-12-3 N-(N-(α-hydroxyisovaleryl)leucyl)proline benzyl ester 
• 876954-01-7 (S)-1-((S)-2-{(S)-2-[(3S,4R)-4-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hexanoyloxy]-3-methyl-butyrylamino}-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzyl ester 
• 945473-75-6 O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester 
• 945473-49-4 O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine 
• 766513-82-0 C₅₇H₇₉N₅O₁₅ 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 22838-58-0 Boc-D-Val-OH 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 89545-43-7 H-Leu-Pro-OBzl hydrochloride 
• 120219-31-0 L-N-(tert-butoxycarbonyl)serine phenacyl ester 
• 182360-34-5 D-N-(tert-butoxycarbonyl)valine pentafluorophenyl ester 

Relevant academic research and scientific papers

Total synthesis and biological evaluation of tamandarin B analogues

(Chemical Equation Presented) Tamandarins A and B are a class of marine natural cyclodepsipeptides with structures and biological activities closely related to those of the didemnins. The easier synthetic access to tamandarins accelerates the preparation of new macrocyclic derivatives of this family of antitumor, antiviral, and immunosuppressive compounds. The optimization of the previously reported synthetic route to tamandarins by changing the macrolactamization site from Nst1 and Thr6 to Pro 4 and N,O-Me2Tyr5 residues led to a significant improvement in the reaction yield. Using this new synthetic approach, four new macrocyclic analogues of tamandarin B were prepared and evaluated for anticancer activity. These results provide further insight into the structure-activity relationship of the tamandarins and didemnins.