182363-41-3Relevant academic research and scientific papers
Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies
Kumar, Bhupinder,Sharma, Praveen,Gupta, Vivek Prakash,Khullar, Madhu,Singh, Sandeep,Dogra, Nilambra,Kumar, Vinod
, p. 130 - 140 (2018/03/23)
A number of pyrimidine bridged combretastatin derivatives were designed, synthesized and evaluated for anticancer activities against breast cancer (MCF-7) and lung cancer (A549) cell lines using MTT assays. Most of the synthesized compounds displayed good
Synthesis and biological evaluation of substituted 4,6-diarylpyrimidines and 3,5-diphenyl-4,5-dihydro-1H-pyrazoles as anti-tubercular agents
Pathak, Vinay,Maurya, Hardesh K.,Sharma, Sandeep,Srivastava, Kishore K.,Gupta, Atul
, p. 2892 - 2896 (2014/06/10)
Various substituted 4,6-diarylpyrimidin-2-amine (4), 4,6-diaryl-2- (heteroaryl)pyrimidine (6) and 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl) ethanone (7) derivatives were synthesized in good yields using simple methodology. The synthesized compounds (4-7)
Fused heterocyclic ring systems from amino- and thioxo-pyrimidine derivatives
Mahmoud,Abd-El-Halim,Ebrahim, Awatef E. F.,Radwan
, p. 915 - 919 (2007/10/03)
1-(p-Anisyl)-3-(3′, 4′, 5′-trimethoxyphenyl)prop-2-en-1-one (1) when reacts with guanidine hydrochloride and thiourea yields aminopyrimidine 2 and pyrimidinethione 8, respectively. The behaviour of 2 and 8 towards some electrophiles and nitrogen nucleophiles has been investigated.
