18239-50-4

Usage

InChI:InChI=1/C18H19NO/c1-3-7-16(8-4-1)15-18(17-9-5-2-6-10-17)19-11-13-20-14-12-19/h1-10,15H,11-14H2

Upstream product

• 5765-65-1 4-(benzoyloxy)morpholine 
• 20259-38-5 cis-Stilbenyl-diisobutyl-aluminium 
• 501-65-5 diphenyl acetylene 
• 110-91-8 morpholine 

Downstream Products

• 4591-62-2 4-(4-nitro-1,2-diphenyl-but-1-enyl)-morpholine 
• 4983-78-2 3-Benzoyl-2,3-diphenylnitropropan 
• 56569-78-9 4-(3,4-diphenyl-[1,2]dioxetan-3-yl)-morpholine 
• 127936-42-9 4,5-dimethyl-2-(1-morpholino-1,2-diphenylethyl)-2-oxo-1,3,2-dioxaphospholane 
• 131941-24-7 5-nitro-2,3-diphenylpyridine 
• 451-40-1 phenyl benzyl ketone 
• 720-43-4 2-fluoro-1,2-diphenylethanone 
• 127529-30-0 4-(1,2-diphenylethyl)morpholine 
• 365-01-5 2,2-difluoro-2-phenylacetophenone 

Relevant academic research and scientific papers

Achieving Aliphatic Amine Addition to Arylalkynes via the Lewis Acid Assisted Triazole-Gold (TA-Au) Catalyst System

Transition metal catalyzed intermolecular hydroamination of the arylalkynes with aliphatic amine is generally problematic due to the good coordination between amine and metal cation. With the combination of 1,2,3-triazole coordinated gold(I) catalyst (TA-Au) and Zn(OTf)2 cocatalyst, this challenging transformation was achieved with good to excellent yields and regioselectivity. Compared to previously reported methods, this approach offered an alternative catalyst system to achieve this fundamental chemical transformation with high efficiency and practical conditions.

Cu-Catalyzed electrophilic amination of internal alkynes via hydroalumination

A straightforward and efficient method for the synthesis of 1,2-diaryl-substituted enamines through the Cu-catalyzed electrophilic amination reaction of O-benzoyl hydroxylamines with vinylaluminum reagents generated in situ from the Ni-catalyzed hydroalumination of readily accessible internal aryl acetylenes is described. The amination is catalyzed by 1 mol% CuCl without any additive at ambient temperature to afford new versatile enamines in good yield (61-91%) with high selectivity (>98% E-enamine).

NOVEL CATALYSTS

The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions.