1824-58-4 Usage
Originator
Ethiazide,Tokyo Tanabe,Japan,1970
Manufacturing Process
A mixture of 2.9 grams of 5-chloro-2,4-disulfamyl-aniline in 20 ml of
anhydrous diethylene glycoldimethylether, 0.44 gram of propionaldehyde and
0.5 ml of a solution of hydrogen chloride in ethyl acetate (109.5 grams
hydrogen chloride per 1,000 ml) is heated to 80° to 90°C and maintained at
that temperature for 1 hour. The reaction mixture is concentrated under
reduced pressure; on addition of water, the product separates and is then
recrystallized from ethanol or aqueous ethanol to yield the desired 6-chloro-3-
ethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide, MP 269° to
270°C.
Therapeutic Function
Diuretic, Cardiotonic, Smooth muscle relaxant,
Respiratory stimulant
Check Digit Verification of cas no
The CAS Registry Mumber 1824-58-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,2 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1824-58:
(6*1)+(5*8)+(4*2)+(3*4)+(2*5)+(1*8)=84
84 % 10 = 4
So 1824-58-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H12ClN3O4S2/c1-2-9-12-6-3-5(10)7(18(11,14)15)4-8(6)19(16,17)13-9/h3-4,9,12-13H,2H2,1H3,(H2,11,14,15)
1824-58-4Relevant articles and documents
A convenient and mild cyclocondensation using water-soluble aldehydes in water
Kitanosono, Taku,Cho, Soo Min,Kobayashi, Shū
, p. 7237 - 7241 (2018)
The use of negatively charged aluminosilicate layers and Lewis acidic cations embedded therein allowed efficient cyclocondensation of bisamines with water-soluble aldehydes to be achieved in water. The protocol does not involve acidic or reflux conditions, thereby avoiding undesired byproduct formation. The use of water as a reaction medium is indispensable to ensure high reaction yields.
Synthesis of chlorothiazide and dihydrochlorothiazide derivatives.
CRAVERI,ZONI
, p. 956 - 971 (2007/10/05)
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