182438-97-7

Basic information

• Product Name: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-
• Synonyms: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-
• CAS NO: 182438-97-7
• Molecular Formula: C₁₈H₁₇BrO₂
• Molecular Weight: 345.23038
• EINECS: -0
• Mol File: 182438-97-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-(182438-97-7)
• EPA Substance Registry System: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-(182438-97-7)

Safety Data

• Hazardous Substances Data: 182438-97-7(Hazardous Substances Data)

Usage

General Description

9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)- is a chemical compound that contains a fluorene core structure with a carboxylic acid group located at the 9-position. Additionally, it has a 4-bromobutyl group attached to the 9-position of the fluorene structure. 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)- can be used in organic synthesis and chemical research applications. It may have potential uses in the development of pharmaceuticals, agrochemicals, and materials science due to its unique structure and properties. Additionally, it may also have uses in the field of organic electronics and as a precursor to various functionalized fluorene derivatives in chemical synthesis.

Upstream product

• 62168-25-6 1,1-dibromobutane 
• 1989-33-9 9H-fluorene-9-carboxylic acid 
• 110-52-1 1,4-dibromo-butane 

Downstream Products

• 182431-12-5 9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide 
• 202914-84-9 N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4’-(trifluoromethyl)[1,1‘-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate 
• 182438-98-8 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide 
• 223559-49-7 (2-oxo-2-{4-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-2λ⁵-[1,3,2]dioxaphosphinan-5-yl)-carbamic acid benzyl ester 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF LOMITAPIDE

The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

Method for synthesizing triglyceride transfer protease inhibitor

The invention discloses a method for synthesizing the triglyceride transfer protease inhibitor Lomitapide. Specifically, based on improvement of an existing technique, the compounds 9-carboxyfluorene and 1,4-dibromobutane are used as raw materials, five-step reaction is conducted, and the defects of the prior art are overcome. Compared with the prior art, the method has the main advantage that column chromatography purification is avoided, and product purification is conducted with a recrystallization method which is economical and environment-friendly.

CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD

Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0,1 or 2; R is H, alkyl, aryl or halogen; A is (1) a bond; (2) -O-; or (3) (i); B is: (ii) or (iii) or (iv) or (v) (wherein (a = 2, 3 or 4)) or (vi) or (vii) or (viii); and wherein L, L, R, R, R, R, R, R, R, R, R, X, (ix), (x) and (xi) are as defined herein.