182439-40-3

Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-2-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-4'-(trifluoromethyl)is used as a potential therapeutic agent for various medical conditions due to its unique chemical structure and potential biological activities.
Used in Agrochemical Industry:
In the agrochemical sector, [1,1'-Biphenyl]-2-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-4'-(trifluoromethyl)may be utilized as a component in the development of novel pesticides or herbicides, leveraging its chemical properties to target specific pests or weeds.
Used in Material Science:
[1,1'-Biphenyl]-2-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-4'-(trifluoromethyl)could be employed in material science for the creation of new materials with specific properties, such as enhanced stability or reactivity, depending on the compound's characteristics once fully understood.
Further research is necessary to explore the specific properties and potential applications of [1,1'-Biphenyl]-2-carboxamide, N-[1-(phenylmethyl)-4-piperidinyl]-4'-(trifluoromethyl)in these industries.

Upstream product

• 50541-93-0 4-amino-1-benzylpiperidine 
• 84392-17-6 4'-(trifluoromethyl)-2-biphenylcarboxylic acid 
• 180340-74-3 4'-trifluoromethylbiphenyl-2-carbonyl chloride 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 182439-41-4 N-(1-piperidin-4-yl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide 
• 182431-12-5 9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide 

Relevant academic research and scientific papers

AMORPHOUS FORM OF LOMITAPIDE MESYLATE

Provided is novel amorphous form of lomitapide mesylate salt and process for preparation thereof.

PROCESS FOR THE PREPARATION OF LOMITAPIDE

The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

ESTER COMPOUND AND MEDICINAL USE THEREOF

A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1") (wherein ???R1 and R2 are each hydrogen atom or optionally substituted aryl, etc.; ???X is -COO- or -CON(R10)-; ???R3 and R4 are each hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy, etc.; ???R5, R6 and R7 are each hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy, etc.; ???R8 and R9 are each independently hydrogen atom, C1-C6 alkyl, -CON(R18)(R19) or -COO(R20), etc.; ???ring A, ring B and ring C are each independently aryl or heterocycle residue, etc.; ???Alk1 and Alk2 are each independently alkanediyl, etc.; ???l and m are each an integer of 0 or 1 to 3) or a prodrug thereof, or a pharmaceutically acceptable salt of either. The therapeutic agent selectively inhibits MTP in the small intestine, thus causes no such side effect as a fatty liver.

Biphenyl derivatives, production thereof and uses as medicines

The present invention relates to biphenyl derivatives of general formula wherein Rato Rgand n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.