18245-82-4

Usage

Uses

Used in Organic Synthesis:
1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE is used as a building block in organic synthesis for the production of various organic compounds, contributing to the creation of a wide range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE is used as a key intermediate in the synthesis of drugs, playing a crucial role in the development of new medicinal agents.
Used in Agrochemical Industry:
1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE is also utilized in the agrochemical sector for the synthesis of pesticides, helping to develop effective solutions for pest control in agriculture.
Used in Material Science:
In the field of material science, 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE is used as a starting material for the production of functionalized silicon compounds, which have potential applications in various high-tech materials.

InChI:InChI=1/C7H11ClOSi/c1-10(2,3)5-4-7(9)6-8/h6H2,1-3H3

Upstream product

• 79-04-9 chloroacetyl chloride 
• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 329203-85-2 2-methyl-4-[(trimethylsilyl)ethynyl]-1,3-thiazole 

Relevant academic research and scientific papers

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18

Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: Discovery and computational modeling of a new series of ligands with nanomolar affinity

Abstract Metabotropic glutamate receptor 5 (mGlu5) is a biological target implicated in major neurological and psychiatric disorders. In the present study, we have investigated structural determinants of the interaction of negative allosteric m

Catalysis by zeolite leading to the construction of thiazole ring: An improved synthesis of 4-alkynyl substituted thiazoles

Zeolite H-beta facilitated the reaction of α-chloro acetyl chloride with 1,2-bis-trimethyl silyl acetylene to give 1-chloro-4-(trimethylsilyl)but-3- yn-2-one which on treatment with thioacetamide afforded 2-methyl-4- [(trimethylsilyl)ethynyl]thiazole. l-P

Convergent synthesis of the quinolone substructure of BILN 2061 via carbonylative sonogashira coupling/cyclization

A convergent synthesis of quinolone 2 (key substructure of the protease inhibitor BILN 2061) was developed via palladium-catalyzed carbonylation of 2-iodo-5-methoxy-aniline (4) with thiazolylacetylene 5.

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol- 4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications

Recent genetic and pharmacological studies have suggested that the metabotropic glutamate receptor subtype 5 (mGluR5) may represent a druggable target in identifying new therapeutics for the treatment of various central nervous system disorders including drug abuse. In particular, considerable attention in the mGluR5 field has been devoted to identifying ligands that bind to the allosteric modulatory site, distinct from the site for the primary agonist glutamate. Both 2-methyl-6-(phenylethynyl)pyridine (MPEP) and its analogue 3-[(2-methyl-4-thiazolyl)ethynyl]pyridine (MTEP) have been shown to be selective and potent noncompetitive antagonists of mGluR5. Because of results presented in this study showing that MTEP prevents the reinstatement of cocaine self-administration caused by the presentation of environmental cues previously associated with cocaine availability, we have prepared a series of analogues of MTEP with the aim of gaining a better understanding of the structural features relevant to its antagonist potency and with the ultimate aim of investigating the effects of such compounds in blunting the self-administration of cocaine. These efforts have led to the identification of compounds showing higher potency as mGluR5 antagonists than either MPEP or MTEP. Two compounds 19 and 59 exhibited functional activity as mGluR5 antagonists that are 490 and 230 times, respectively, better than that of MTEP.

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

2-Methyl-6-(phenylethynyl)pyridine (3), a potent noncompetitive mGlu5 receptor antagonist widely used to characterize the pharmacology of mGlu5 receptors, suffers from a number of shortcomings as a therapeutic agent, including off-target activity and poor

1,3-Diethynylallenes: Carbon-rich modules for three-dimensional acetylenic scaffolding

Regioselective Pd0-catalyzed cross-coupling of substrates, which bear bispropargylic leaving groups with silyl-protected alkynes, has provided access to a variety of 1,3-diethynylallenes, a new family of modules for three-dimensional acetylenic