18245-82-4

Basic information

• Product Name: 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE
• Synonyms: 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE;1-chloro-4-(triMethylsilyl)but-3-yn-2-one;1-Chloro-4-(trimethylsilyl)-3-butyn-2-one
• CAS NO: 18245-82-4
• Molecular Formula: C7H11ClOSi
• Molecular Weight: 174.70014
• Mol File: 18245-82-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 187℃
• Flash Point: 70℃
• Appearance: /
• Density: 1.017
• Vapor Pressure: 0.643mmHg at 25°C
• Refractive Index: 1.45
• CAS DataBase Reference: 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE(18245-82-4)
• EPA Substance Registry System: 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE(18245-82-4)

Safety Data

• Hazardous Substances Data: 18245-82-4(Hazardous Substances Data)

Usage

General Description

1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE is a chemical compound with the molecular formula C7H11ClOSi. It is a chlorinated silane compound containing a butynone group, which is a type of organic chemical compound. 1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE is used in organic synthesis and can be used as a building block for the production of various organic compounds. It is also used in pharmaceutical and agrochemical industries for the synthesis of various drugs and pesticides. This chemical has potential applications in the field of material science and can be used as a starting material for the production of functionalized silicon compounds.

InChI:InChI=1/C7H11ClOSi/c1-10(2,3)5-4-7(9)6-8/h6H2,1-3H3

Upstream product

• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 1066-54-2 trimethylsilylacetylene 
• 79-04-9 chloroacetyl chloride 
• 14630-40-1 Bis(trimethylsilyl)ethyne 

Downstream Products

• 329203-85-2 2-methyl-4-[(trimethylsilyl)ethynyl]-1,3-thiazole 

Relevant articles and documents

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18

Catalysis by zeolite leading to the construction of thiazole ring: An improved synthesis of 4-alkynyl substituted thiazoles

Zeolite H-beta facilitated the reaction of α-chloro acetyl chloride with 1,2-bis-trimethyl silyl acetylene to give 1-chloro-4-(trimethylsilyl)but-3- yn-2-one which on treatment with thioacetamide afforded 2-methyl-4- [(trimethylsilyl)ethynyl]thiazole. l-P

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol- 4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications

Recent genetic and pharmacological studies have suggested that the metabotropic glutamate receptor subtype 5 (mGluR5) may represent a druggable target in identifying new therapeutics for the treatment of various central nervous system disorders including drug abuse. In particular, considerable attention in the mGluR5 field has been devoted to identifying ligands that bind to the allosteric modulatory site, distinct from the site for the primary agonist glutamate. Both 2-methyl-6-(phenylethynyl)pyridine (MPEP) and its analogue 3-[(2-methyl-4-thiazolyl)ethynyl]pyridine (MTEP) have been shown to be selective and potent noncompetitive antagonists of mGluR5. Because of results presented in this study showing that MTEP prevents the reinstatement of cocaine self-administration caused by the presentation of environmental cues previously associated with cocaine availability, we have prepared a series of analogues of MTEP with the aim of gaining a better understanding of the structural features relevant to its antagonist potency and with the ultimate aim of investigating the effects of such compounds in blunting the self-administration of cocaine. These efforts have led to the identification of compounds showing higher potency as mGluR5 antagonists than either MPEP or MTEP. Two compounds 19 and 59 exhibited functional activity as mGluR5 antagonists that are 490 and 230 times, respectively, better than that of MTEP.