18246-23-6Relevant articles and documents
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Benkeser,Torkelson
, p. 1252 (1954)
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Generation and Synthetic Utility of Dianions Derived from Thiophencarboxylic Acids
Knight, David W.,Nott, Andrew P.
, p. 791 - 794 (2007/10/02)
Thiophen-2- and -3-carboxylic acid are rapidly and regioselectively metallated by lithium di-isopropylamide in tetrahydrofuran at -78 deg C.The resulting dianionic species react with a range of electrophiles to give the expected thiophencarboxylic acid homologues in good-to-excellent yields.