182625-84-9Relevant academic research and scientific papers
Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
Schlegel, Mark K.,Foster, Donald J.,Kel'In, Alexander V.,Zlatev, Ivan,Bisbe, Anna,Jayaraman, Muthusamy,Lackey, Jeremy G.,Rajeev, Kallanthottathil G.,Charissé, Klaus,Harp, Joel,Pallan, Pradeep S.,Maier, Martin A.,Egli, Martin,Manoharan, Muthiah
, p. 8537 - 8546 (2017)
Here we report the investigation of glycol nucleic acid (GNA), an acyclic nucleic acid analogue, as a modification of siRNA duplexes. We evaluated the impact of (S)- or (R)-GNA nucleotide incorporation on RNA duplex structure by determining three individu
Biologically active oligodeoxyribonucleotides. 10: Anti-HIV-1 activity and stability of modified hexanucleotides containing glycerol-skeleton
Hotoda, Hitoshi,Koizumi, Makoto,Ohmine, Toshinori,Furukawa, Hidehiko,Nishigaki, Takashi,Abe, Koji,Kosaka, Toshiyuki,Tsutsumi, Shinya,Sone, Junko,Kaneko, Masakatsu,Kimura, Satoshi,Shimada, Kaoru
, p. 243 - 252 (2007/10/03)
Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which exhibits anti-HIV-1 activity, were partially replaced with glycerol-moieties. Compound 7 with two glycerylguanines at its 3'-end showed more potent anti- HIV-1 activity and more stability a
