18266-55-2

Usage

Uses

Used in Polymer Production:
N-(2-HYDROXYETHYL)PROPIONAMIDE is used as a chemical intermediate for the synthesis of polymers, contributing to the development of materials with specific properties for various applications.
Used in Resin Production:
In the resin industry, N-(2-HYDROXYETHYL)PROPIONAMIDE is used as a component in the formulation of various resins, enhancing their performance and versatility in different applications.
Used in Pharmaceutical Industry:
N-(2-HYDROXYETHYL)PROPIONAMIDE is used as a key ingredient in the development of pharmaceuticals, playing a crucial role in the synthesis of drugs with potential therapeutic benefits.
Used in Chemical Reactions for Medical and Scientific Research:
N-(2-HYDROXYETHYL)PROPIONAMIDE is employed as a reactant in several chemical reactions, resulting in products that are of significant interest in the fields of medicine and scientific research, potentially leading to the discovery of new compounds with valuable properties.

InChI:InChI=1/C5H11NO2/c1-2-5(8)6-3-4-7/h7H,2-4H2,1H3,(H,6,8)

Upstream product

• 141-43-5 ethanolamine 
• 802294-64-0 propionic acid 
• 105-37-3 Ethyl propionate 
• 79-03-8 propionyl chloride 
• 75-07-0 acetaldehyde 
• 79-05-0 Propionamid 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 10431-98-8 2-ethyl-4,5-dihydrooxazole 
• 16982-46-0 2-ethyl-2-thiazoline 
• 39931-57-2 8-methyl-5-phenyl-2,3-dihydro-thiazolo[3,2-c]pyrimidin-7-one 
• 39931-56-1 6-benzoyl-8-methyl-2,3-dihydro-thiazolo[3,2-c]pyrimidine-5,7-dione 
• 13670-22-9 N-<2-(methylphenylamino)-ethyl>-propanamide 
• 13670-20-7 N-phenyl-N'-propionylethylenediamine 
• 13670-21-8 N-(4-methylphenyl)-N'-propionylethylenediamine 
• 13670-31-0 2-(4,5-dihydro-oxazol-2-yl)-propan-1-ol 
• 10471-78-0 2-(Propen-2-yl)-4,5-dihydro-1,3-oxazole 
• 13670-36-5 2-(1-phenylcarbamoyl-ethylidene)-oxazolidine-3-carboxylic acid anilide 
• 70349-90-5 3'-benzyl-8-methoxy-3-methyl-6-nitro-spiro[chromene-2,2'-thiazolidine] 
• 28221-31-0 2-ethyl-5,6-dihydro-4H-[1,3]thiazine 

Relevant academic research and scientific papers

Preparation method of N-vinyl alkylamide

The invention relates to the technical field of vinyl compound production, in particular to a preparation method of Nvinyl alkyl amide. The preparation method comprises the following steps: A) under the action of a composite basic catalyst, reacting acetaldehyde with alkylamide to obtain Nhydroxyethyl alkylamide, and carrying out esterification reaction on the obtained Nhydroxyethyl alkylamide andacid anhydride to obtain an ester compound; wherein the composite basic catalyst comprises an inorganic base and an amine compound; and B) carrying out medium-temperature cracking on the ester compound, and carrying out vacuum distillation to obtain the Nvinyl alkylamide. Research finds that inorganic base and amine compounds are adopted as catalysts at the same time, so that the dosage of a basic catalyst required by reaction of Nhydroxyethyl alkylamide and anhydride can be remarkably reduced, the temperature required by subsequent cracking reaction is reduced, a reaction system tends to bemilder, and the reaction yield is improved. The yield and the purity of a reaction product can be remarkably improved while the energy consumption is reduced.

Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

Synthesis and anticonvulsant activity of N-(2-hydroxyethyl)amide derivatives

A series novel of N-(2-hydroxyethyl)amide derivatives was synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test, and their neurotoxicity was evaluated by the rotarod test (Tox). The maximal electroshock test showed that N-(2-hydroxyethyl)decanamide 1g, N-(2-hydroxyethyl)palmitamide 1l, and N-(2-hydroxyeth-yl)stearamide 1n were found to show a better anticonvulsant activity and also had lower toxicity than the marked anti-epileptic drug valproate. In the anti-MES potency test, these compounds exhibited median effective doses (ED50) of 22.0, 23.3, 20.5 mg/kg, respectively, and median toxicity doses (TD50) of 599.8, >1000, >1000 mg/kg, respectively, resulting in a protective index (PI) of 27.5, >42.9, >48.8, respectively. This is a much better protective index than that of the marked anti-epileptic drug valproate (PI = 1.6). To further investigate the effects of the anticonvulsant activity in several different models, compounds 1g, 1l, and 1n were tested having evoked convulsions with chemical substances, including pentylenetetrazloe, isoniazide, 3-mercaptopropionic acid, bicuculline, thiosemicarbazide, and strychnine.

Generation of cyclic ketene-N,X-acetals (X = O, S) from 2-alkyl-1,3-oxazolines and 2-alkyl-1,3-thiazolines. Reactions with acid chlorides, 1,3-diacid chlorides and N-(chlorocarbonyl) isocyanate

2-Alkyl-1,3-oxazolines, 2-alkyl-1,3-thiazolines, and the corresponding cyclic ketene-N,X-acetals (X = O, S) derived from them were reacted with monoacid chlorides, diacid chlorides, triacid chlorides. A series of these carbon-carbon bond-forming reactions and cyclizations to both substituted 2,3-dihydrooxazolo[3,2-a]pyridine-5,7-diones and 2,3-dihydrothiazolo[3,2-a] pyridine-5,7-diones proceeded under mild reaction conditions. Cyclic ketene-N,X-acetal intermediates play important roles in all these reactions. Related cyclizations with N-(chlorocarbonyl) isocyanate formed substituted 2,3-dihydrooxazolo[3,2-c]pyrimidine-5,7-diones and 2,3-dihydrothiazolo[3,2-c] pyrimidine-5,7-diones. Georg Thieme Verlag Stuttgart.

Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase α

We reported previously that a novel dipeptide alcohol, l- homoserylaminoethanol (Hse-Gly-ol), is a selective inhibitor of eukaryotic DNA polymerase ε (pol ε) [Bioorg. Med. Chem. 2004, 12, 957-962]. The discovery suggests that the dipeptide structure could