1827-54-9Relevant academic research and scientific papers
Pyridazine compounds and compositions containing the same
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Page column 17, (2008/06/13)
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1represents a (substituted) aryl group, R2represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1β production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.
5,6-Diaryl-2,3-dihydroimidazothiazoles: A New Class of Immunoregulatory Antiinflammatory Agents
Bender, Paul E.,Hill, David T.,Offen, Priscilla H.,Razgaitis, Kazys,Lavanchy, Patricia,et al.
, p. 1169 - 1177 (2007/10/02)
A series of substituted 5,6-diaryl-2,3-dihydroimidazothiazoles were synthesized and evaluated in the rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays to determine the potential of these compounds for use as immu
