182886-67-5Relevant academic research and scientific papers
Synthetic routes for the generation of 7,7-dialkyl azepin-2-ones
Robl, Jeffrey A.,Sieber-McMaster, Ellen,Sulsky, Richard
, p. 8985 - 8988 (2007/10/03)
Three diverse synthetic routes to C-7 dialkylated and spiro-alkylated azepinones are described. Compounds of this type may be used as conformationally restricted dipeptide surrogates. Additionally, the chiral synthesis of novel cyclopropanated lysine derivative 29 is demonstrated. Copyright (C) 1996 Elsevier Science Ltd.
SUBSTITUTED AZEPINONE DUAL INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL EXDOPEPTIDASE
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, (2008/06/13)
Compounds of the formula STR1 are disclosed as possessing inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
