182913-11-7Relevant academic research and scientific papers
Strategies for the synthesis of HBGl3, a glutamic acid derived ligand bearing phenolic and azacarboxylate donor groups at the nitrogen atom
Mulla, Raminder S.,Walden, Melissa T.,Yufit, Dmitry S.,Desa, Tanya,Lurie-Luke, Elena,Williams, J.A. Gareth
, p. 6410 - 6420 (2017/09/29)
The development of a route applicable to the preparation of acyclic glutamic acid-based chelating ligands bearing two different auxiliary donor groups linked to the nitrogen atom by methylene spacers is described and applied to the synthesis of the new polydentate ligand HBGl3, the first example of such a structure. The synthesis is accomplished using a strategy employing reductive amination and t-butyl ester protected intermediates. The most basic pKa values for the HBGl3 ligand have been estimated via potentiometric and UV–Visible titration techniques.
Platinum(II) complexes of reduced amino acid ester Schiff bases: Synthesis, characterization, and antitumor activity
Li, Li-Jun,Wang, Cheng,Qiao, Yu,Yang, Xiao-Yan,Hua, Xing-Xing,Du, Jian-Long
, p. 413 - 424 (2014/02/14)
A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line.
Efficient synthesis of 2,3-disubstituted-1,3-benzoxazines by chlorotrimethylsilane-mediated aza-acetalizations of aromatic aldehydes
Tang, Zilong,Zhu, Zhonghua,Yan, Lin,Chang, Shuhong,Liu, Hanwen
, p. 1116 - 1120 (2013/10/21)
A series of novel substituted 3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to good yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of chlorotrimethylsilane or SnCl4. It w
Synthesis and fungicidal activity of novel 2,3-disubstituted-1,3- benzoxazines
Tang, Zilong,Zhu, Zhonghua,Xia, Zanwen,Liu, Hanwen,Chen, Jinwen,Xiao, Wenjing,Ou, Xiaoming
scheme or table, p. 8174 - 8185 (2012/09/25)
A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed
Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in composition and use thereof
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, (2009/12/02)
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
A new general route to novel azomethine ylides for cycloaddition reactions
Lery, Fran?ois-Xavier,Kunesch, Nicole,George, Pascal,Husson, Henri-Philippe
, p. 1599 - 1614 (2007/10/03)
A general method providing access to stabilized azomethine ylides generated from substituted 1,3- and 3,1-aryloxazines was developed. A two-step sequence based on 1,3-dipolar cycloaddition reactions with N-arylmaleimides was elaborated to give a series of
