69698-15-3

Upstream product

• 90-02-8 salicylaldehyde 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 67-56-1 methanol 
• 6000-43-7 2-aminoethanoic acid hydrochloride 

Downstream Products

• 1261300-44-0 methyl 2-(2-(4-fluorophenyl)-2H-1,3-benzoxazin-3(4H)-yl)acetate 
• 1261300-41-7 methyl 2-(2-(2-nitrophenyl)-2H-1,3-benzoxazin-3(4H)-yl)acetate 
• 1261300-43-9 methyl 2-(2-(4-nitrophenyl)-2H-1,3-benzoxazin-3(4H)-yl)acetate 
• 1261300-42-8 methyl 2-(2-(3-nitrophenyl)-2H-1,3-benzoxazin-3(4H)-yl)acetate 
• 182913-11-7 2-((3-methoxycarbonylmethylamino)methyl)phenol 

Relevant academic research and scientific papers

Strategies for the synthesis of HBGl3, a glutamic acid derived ligand bearing phenolic and azacarboxylate donor groups at the nitrogen atom

The development of a route applicable to the preparation of acyclic glutamic acid-based chelating ligands bearing two different auxiliary donor groups linked to the nitrogen atom by methylene spacers is described and applied to the synthesis of the new polydentate ligand HBGl3, the first example of such a structure. The synthesis is accomplished using a strategy employing reductive amination and t-butyl ester protected intermediates. The most basic pKa values for the HBGl3 ligand have been estimated via potentiometric and UV–Visible titration techniques.

Platinum(II) complexes of reduced amino acid ester Schiff bases: Synthesis, characterization, and antitumor activity

A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line.

Efficient synthesis of 2,3-disubstituted-1,3-benzoxazines by chlorotrimethylsilane-mediated aza-acetalizations of aromatic aldehydes

A series of novel substituted 3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to good yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of chlorotrimethylsilane or SnCl4. It w

Synthesis and fungicidal activity of novel 2,3-disubstituted-1,3- benzoxazines

A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed

Stereocontrolled Synthesis of Highly Substituted Proline Esters via [3 + 2] Cycloaddition between N-Metalated Azomethine Ylides and Nitroalkenes. Origins of the Metal Effect on the Stereochemical Outcome

The [3 + 2] cycloaddition reaction between several N-metalated azomethine ylides and nitroalkenes has been studied using AgOAc and LiClO4 as metalating reagents in the presence of triethylamine. The reaction is found to be very versatile and can be extended to homochiral nitroalkenes. In general, lithium and silver salts promote preferential formation of the endo and exo cycloadducts, respectively. The presence of a phenol moiety induces a shift toward the exo-cycloadduct even when lithium is used. A model based upon the experimental results obtained and SCF-MO calculations is proposed to explain the variable stereochemical outcome of these reactions.

X=Y-ZH Systems as Potential 1,3-Dipoles. Part 8. Pyrrolidines and Δ5-Pyrrolines (3,7-Diazabicyclooctenes) from the Reaction of Imines of α-Amino Acids and their Esters with Cyclic Dipolarophiles. Mechanism of Racemisation of α-Amino Acid

Imines of α-amino acid esters with aromatic, heterocyclic, and aliphatic aldehydes generate azomethine ylides stereospecifically by a prototropic shift on heating in toluene.The azomethine ylides undergo cycloaddition to N-phenylmaleimide, maleic anhydrid