182919-40-0

Upstream product

• 25752-17-4 2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]-thiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 70-11-1 α-bromoacetophenone 
• 15951-21-0 4,5,6,7-tetrahydro-benzothiazol-2-ylamine; hydrochloride 

Downstream Products

• 202482-77-7 (2-Phenyl-5,6,7,8-tetrahydro-benzo[d]imidazo[2,1-b]thiazol-3-yl)-methanol 

Relevant academic research and scientific papers

Synthesis of 2-phenylimidazo[2,1-b]benzothiazole derivatives as modulators of multidrug resistance for tumor cells

We have investigated 3-substituted-2-phenylimidazo[2,1-b]benzothiazole derivatives and herein we have discussed their pharmaceutical activities. We found that some 2-phenyl-5,6,7,8-tetrahydroimidazo[2,1-b]-benzothiazoles could overcome multidrug resistance for tumor cells. Among them, 2-phenyl-3- (N-methyl-3-piperidyl)carbonylaminoiminomethyl-5,6,7,8-tetrahydroimidazo[2,1- b]benzothiazole [N276-12] demonstrated the most potent activity for overcoming multidrug resistance.

Imidazothiazole compound

An imidazothiazole compound having the formula (A): STR1 wherein R1 is a phenyl or napthyl which may have a substituent, R2 is an acyl, and the two bonds at dotted line portions may or may not exist simultaneously, or a pharmacologic