Synthesis of 2-phenylimidazo[2,1-b]benzothiazole derivatives as modulators of multidrug resistance for tumor cells

Article abstract of DOI:10.1002/jhet.5570340620

We have investigated 3-substituted-2-phenylimidazo[2,1-b]benzothiazole derivatives and herein we have discussed their pharmaceutical activities. We found that some 2-phenyl-5,6,7,8-tetrahydroimidazo[2,1-b]-benzothiazoles could overcome multidrug resistance for tumor cells. Among them, 2-phenyl-3- (N-methyl-3-piperidyl)carbonylaminoiminomethyl-5,6,7,8-tetrahydroimidazo[2,1- b]benzothiazole [N276-12] demonstrated the most potent activity for overcoming multidrug resistance.