182925-93-5

Upstream product

• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 182925-82-2 N-(saccharinyl)-acetic acid azide 
• 61020-33-5 2-[1,1-dioxide-3-oxo-1,2-benzisothiazole-2(3H)-yl] acetic acid chloride 
• 128-44-9 saccharin sodium salt 
• 52188-11-1 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid 

Relevant academic research and scientific papers

Synthesis of some saccharin derivatives of expected biological activity based on n-(saccharinyl)-acetic acidazide

Azide 3 was prepared from the corresponding acid chloride 2. The base catalyzed decomposition with aromatic amines, aminobenzoic acids and/or hydrazines afforded the corresponding anilides 4a-f and/or hydrazides 5a-d via azido group displacement. Compounds 5c and 5d were refluxed in Ac2O to give 1,3,4-oxadiazole derivatives 6a and 6b. Lewis acid catalyzed decomposition of azide 3 with anhyd. AlCl3 in dry aromatic substrates gave the corresponding ketones 7a-c. Also, the reaction of azide 3 with glycine gave 9.