Journal of Heterocyclic Chemistry p. 1407 - 1411 (1996)
Update date:2022-08-05
Topics:
Renau, Thomas E.
Sanchez, Joseph P.
Domagala, John M.
A series of 8-bromo-4-oxo-3-quinolinecarboxylic acids was prepared via the borate ester, 8. The key intermediate in the synthesis of the final products 10a-10d was 3-bromo-2,4,5-trifluorobenzoic acid (3), conveniently prepared in two steps from the known oxazoline, 1. The preparation of 10a-10d is a significant improvement of the literature procedure currently available for the synthesis of these compounds.
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Doi:10.1021/ja9620797
(1996)Doi:10.1007/BF01176965
(1996)Doi:10.1016/S0968-0896(98)80010-2
(1998)Doi:10.1016/S0040-4039(00)79965-5
(1994)Doi:10.1002/jlac.199619961111
(1996)Doi:10.1080/07328319608002458
(1996)
