The synthesis of 3-bromo-2,4,5-trifluorobenzoic acid and its conversion to 8-bromoquinolonecarboxylic acids

Article abstract of DOI:10.1002/jhet.5570330466

A series of 8-bromo-4-oxo-3-quinolinecarboxylic acids was prepared via the borate ester, 8. The key intermediate in the synthesis of the final products 10a-10d was 3-bromo-2,4,5-trifluorobenzoic acid (3), conveniently prepared in two steps from the known oxazoline, 1. The preparation of 10a-10d is a significant improvement of the literature procedure currently available for the synthesis of these compounds.