182953-78-2

Upstream product

• 7605-28-9 2-(phenylsulfonyl)acetonitrile 
• 153361-01-4 6-(tert-butyl(diphenyl)silanyloxy)-hex-2-enal 
• 182953-77-1 (2E,4E)-8-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-octa-2,4-dienoic acid ethyl ester 

Downstream Products

• 180866-32-4 (7E,9E)-(R)-13-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-trideca-1,7,9-trien-4-ol 
• 180866-34-6 tert-Butyl-((4E,6E)-(R)-10-methoxy-7-methyl-trideca-4,6,12-trienyloxy)-diphenyl-silane 
• 180866-33-5 (4E,6E)-10-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-deca-4,6-dienal 
• 155233-30-0 curacin A 
• 182953-79-3 (4E,6E)-10-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-deca-4,6-dienenitrile 

Relevant academic research and scientific papers

Synthesis of curacin A, an antimitotic cyclopropane-thiazoline from the marine cyanobacterium Lyngbya majuscula

Charette asymmetric cyclopropanation, chiral thiazoline synthesis by thioamide cyclization under modified Mitsunobu conditions, Ti(iPrO)4/bi-naphthol catalyzed allylstannane addition, and an exceptionally mild two-carbon homologation via dehydrative alkylation with phenylsulfonylacetonitrile/Ph3P/ADDP convened in an efficient, stereocontrolled route to the title bioactive heterocycle.