183064-07-5

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 179178-40-6 4'-C-benzoyloxymethylthymidine 
• 76054-81-4 3'-O-(4,4'-dimethoxytrityl)thymidine 
• 50-89-5 thymidine 
• 179178-39-3 3'-O-(4,4'-dimethoxytrityl)-4'-hydroxymethylthymidine 
• 179178-38-2 3'-O-(4,4'-dimethoxytrityl)-5'-formylthymidine 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 63861-63-2 4'-hydroxymethyl-thymidine 
• 164267-52-1 5'-O-tert-butyldimethylsilyl-3'-O-(4,4'-dimethoxytriphenylmethyl)thymidine 

Downstream Products

• 179178-49-5 N-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2,2,2-trifluoro-acetamide 

Relevant academic research and scientific papers

Synthesis and evaluation of oligodeoxynucleotides containing 4'-C-substituted thymidines

4'-C-Hydroxymethylthymidine was converted to 4'-C-methoxymethylthymidine and 4'-C-aminomethylthymidine, which were incorporated into oligodeoxynucleotides by phosphoramidite chemistry. The modified oligonucleotides exhibit excellent hybridization and significant improvement in stability to snake venom phosphodiesterase.