179178-40-6

Upstream product

• 98-88-4 benzoyl chloride 
• 63861-63-2 4'-hydroxymethyl-thymidine 
• 76054-81-4 3'-O-(4,4'-dimethoxytrityl)thymidine 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 179178-38-2 3'-O-(4,4'-dimethoxytrityl)-5'-formylthymidine 
• 50-89-5 thymidine 
• 164267-52-1 5'-O-tert-butyldimethylsilyl-3'-O-(4,4'-dimethoxytriphenylmethyl)thymidine 
• 179178-39-3 3'-O-(4,4'-dimethoxytrityl)-4'-hydroxymethylthymidine 

Downstream Products

• 183064-05-3 Benzoic acid (2S,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-ylmethyl ester 
• 183064-07-5 Benzoic acid (2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 179178-43-9 5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylenethymidine 
• 179178-49-5 N-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2,2,2-trifluoro-acetamide 

Relevant academic research and scientific papers

Sugar modified nucleosides and their use for synthesis of oligonucleotides

A number of modified nucleosides are disclosed composed of modified sugar moieties which contain substituents at C1 and C4 positions, or branched substituents at C3 and C5 positions of deoxyribose or ribose. Each nucleoside is converted to or properly pro

Synthesis and evaluation of oligodeoxynucleotides containing 4'-C-substituted thymidines

4'-C-Hydroxymethylthymidine was converted to 4'-C-methoxymethylthymidine and 4'-C-aminomethylthymidine, which were incorporated into oligodeoxynucleotides by phosphoramidite chemistry. The modified oligonucleotides exhibit excellent hybridization and significant improvement in stability to snake venom phosphodiesterase.