179178-38-2Relevant academic research and scientific papers
4′-Epi-DNA: A DNA Mimic Containing 4′-hydroxymethyl-α-l-Xylo-Thymidine with Compact Backbone like RNA
Bagmare, Seema,Puranik, Vedavati G.,Fernandes, Moneesha,Kumar, Vaijayanti A.
, p. 445 - 458 (2016)
Synthesis of C4′-epi-DNA containing 3′→ 5″ linkages is reported for the first time. Crystal structure study of the monomer indicated that though the dihedral angle O3′-C3′-C4′-C5″ in this case would be like in RNA, the sugar conformation would remain like that in DNA. The study of the effect of this backbone configuration in DNA with respect to its binding to cDNA and RNA is reported in this note.
Nucleoside 5′-C-phosphonates: reactivity of the α-hydroxyphosphonate moiety
Králíková, ?árka,Budě?ínky, Milo?,Masojídková, Milena,Rosenberg, Ivan
, p. 4917 - 4932 (2007/10/03)
We found that various dialkyl phosphites, dialkyl trimethylsilyl phosphites, and tris-trimethylsilyl phosphite reacted smoothly with nucleoside 5′-aldehydes to afford epimeric nucleoside 5′-C-phosphonates in high yields. A number of these compounds in bot
Synthesis and evaluation of oligodeoxynucleotides containing 4'-C-substituted thymidines
Wang, Guangyi,Seifert, Wilfried E.
, p. 6515 - 6518 (2007/10/03)
4'-C-Hydroxymethylthymidine was converted to 4'-C-methoxymethylthymidine and 4'-C-aminomethylthymidine, which were incorporated into oligodeoxynucleotides by phosphoramidite chemistry. The modified oligonucleotides exhibit excellent hybridization and significant improvement in stability to snake venom phosphodiesterase.
