18310-19-5Relevant academic research and scientific papers
Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible
Galanski, Markus,Yasemi, Afshin,Slaby, Susanna,Jakupec, Michael A.,Arion, Vladimir B.,Rausch, Monika,Nazarov, Alexey A.,Keppler, Bernhard K.
, p. 707 - 714 (2004)
Oxaliplatin, (trans-R,R-cyclohexane-1,2-diamine)oxalatoplatinum(II), has recently been approved for combination chemotherapy of metastatic colorectal cancer. Oxaliplatin is significantly more active than its trans-S,S isomer and the mixture of both enanti
Methyl-substituted trans-1,2-cyclohexanediamines as new ligands for oxaliplatin-type complexes
Habala, Ladislav,Dworak, Claudia,Nazarov, Alexey A.,Hartinger, Christian G.,Abramkin, Sergey A.,Arion, Vladimir B.,Lindner, Wolfgang,Galanski, Markus,Keppler, Bernhard K.
, p. 137 - 146 (2008/09/17)
Three different pathways for the synthesis of substituted trans-(±)-1,2-cyclohexanediamines as new ligands for oxaliplatin-type compounds are presented. The different synthetic routes lead (i) by the synthesis of the compound via ortho-bromination of a su
