636563-62-7

Basic information

• Product Name: 1,2-Cyclohexanediamine,4-methyl-,(1R,2R)-rel-(9CI)
• Synonyms: 1,2-Cyclohexanediamine,4-methyl-,(1R,2R)-rel-(9CI)
• CAS NO: 636563-62-7
• Molecular Formula: C7H16N2
• Molecular Weight: 128.21534
• Product Categories: AMINEPRIMARY
• Mol File: 636563-62-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Cyclohexanediamine,4-methyl-,(1R,2R)-rel-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanediamine,4-methyl-,(1R,2R)-rel-(9CI)(636563-62-7)
• EPA Substance Registry System: 1,2-Cyclohexanediamine,4-methyl-,(1R,2R)-rel-(9CI)(636563-62-7)

Safety Data

• Hazardous Substances Data: 636563-62-7(Hazardous Substances Data)

Usage

Stereospecific Isomer

(1R,2R)-rel

Explanation

Different sources of media describe the Explanation of 636563-62-7 differently. You can refer to the following data:
1. This term indicates that the compound is a stereospecific isomer of 1,2-cyclohexanediamine, meaning it has the same molecular formula but a different arrangement of atoms in space.
2. The compound is used as a building block in the synthesis of various chemicals, including those used in the pharmaceutical, agrochemical, and fine chemical industries.
3. The compound is used in the production of epoxy resins, which are versatile materials with applications in the manufacturing of adhesives, coatings, and composite materials.
4. The compound has applications in analytical chemistry, which involves the study and analysis of chemical substances and their interactions.
5. The compound serves as a reagent in various chemical reactions, helping to facilitate specific transformations or processes.
6. The compound has a chiral center, which means it can exist in different forms that are mirror images of each other (enantiomers). The (1R,2R)-rel designation indicates the specific configuration of the chiral centers in this compound.

Industrial Applications

Pharmaceutical, Agrochemical, and Fine Chemical Synthesis

Epoxy Resin Production

Adhesives, Coatings, and Composite Materials

Analytical Chemistry

Uses in the field

Reagent in Chemical Reactions

Facilitating specific reactions

Chirality

Presence of a chiral center

Upstream product

• 1246967-42-9 (4S)-4-methyl-1,2-cyclohexanediazide 
• 57567-84-7 C₉H₁₄O₄ 
• 18310-19-5 4-methylcyclohexane-1,2-dione dioxime 
• 1246967-35-0 4-methyl-trans-(+/-)-1,2-diazidocyclohexane 
• 19438-60-9 4-methyl-hexahydrophthalic anhydride 
• 589-92-4 1-methylcyclohexan-4-one 
• 27579-55-1 2-bromo-4-methylcyclohexanone 
• 591-47-9 4-methylcyclohexene 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 2687-25-4 3-methyl-1,2-benzenediamine 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 

Relevant articles and documents

{(1 R,2 R,4 R)-4-Methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): A Novel Enantiomerically Pure Oxaliplatin Derivative Showing Improved Anticancer Activity in Vivo

Novel derivatives of the clinically established anticancer drug oxaliplatin were synthesized. Cytotoxicity of the compounds was studied in six human cancer cell lines by means of the MTT assay. Additionally, most promising complexes were also investigated in cisplatin- and oxaliplatin-resistant human cancer cell models. The therapeutic efficacy in vivo was studied in the murine L1210 leukemia model. Most remarkably, {(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine} oxalatoplatinum(II), comprising an equatorial methyl substituent at position 4 of the cyclohexane ring, was as potent as oxaliplatin in vitro but distinctly more effective in the L1210 model in vivo at the optimal dose. The advantage observed in the in vivo situation was mainly based on a more favorable therapeutic index. The maximum tolerated dose of the novel analogue was higher than that of oxaliplatin and caused a greater increase in life span (>200% versus 152%), with more animals experiencing long-term survival (5/6 versus 2/6). These data support further (pre)clinical development of the methyl-substituted oxaliplatin analogue with improved anticancer activity.

METHOD FOR PRODUCING 1,2-DIAMINO-3-METHYLCYCLOHEXANE AND/OR 1,2-DIAMINO-4-METHYLCYCLOHEXANE

The invention relates to a method for producing 1,2-diamino-3-methylcyclohexane and/or 1,2-diamino-4-methylcyclohexane by reacting 2,3- and/or 3,4-diaminotoluol with hydrogen under high pressure and high temperature in the presence of a heterogene catalys