183115-58-4

Upstream product

• 814-49-3 diethyl chlorophosphate 
• 589-57-1 diethyl phosphorylchloridite 
• 214046-46-5 (R)-1-[3,5-O-(3-benzoyloxy-1-methoxypropylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine 
• 55612-11-8 5'-O-trityldeoxyxylothymidine 
• 5325-72-4 methyl 3-benzoyloxypropioimidate hydrochloride 
• 5325-95-1 3-benzoyloxypropionitrile 
• 214038-73-0 trimethyl 3-benzoyloxyorthopropionate 
• 98-88-4 benzoyl chloride 

Relevant academic research and scientific papers

3',5'-O-phosphonoalkylidene derivatives of 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine: Synthesis and reactivity

Various 3',5'-O-(1-phosphonoalkylidene) derivatives of 1-(2-deoxy-β-D- threo-pentofuranosyl)thymine bearing a substituent in the ω-position of the alkylidene chain were prepared by the redox reaction of diethyl chlorophosphite with six-membered 3',5'-orthoesters of xylo-dT. Susceptibility of ω-haloalkylidene derivatives for nucleophilic substitution is discussed. The configuration of the final phosphonates was determined by 2D-ROESY NMR experiments.

Synthesis of Some Derivatives of 1-thymine Substituted in the ω-Position of the Alkylidene Moiety

Some ω-substituted derivatives of 1-thymine have been prepared.A key step in the synthesis is the reaction of chlorodiethylphosphite with cyclic 3',5'-O-(1-alkoxy)alkylidene nucleoside orthoesters bearing a substituent in the ω-position of the alkylidene moiety.