183171-83-7

Upstream product

• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 57918-71-5 1-Phenyl-2-propanone Potassium Enolate 
• 611-94-9 4-Methoxybenzophenone 
• 133349-85-6 1-(4''-methoxybenzyl)-1H-benzo[d][1.2.3]triazole 
• 98-86-2 acetophenone 
• 19810-20-9 4-methoxy-α-phenyl-β-methylstyrene 

Downstream Products

• 102763-02-0 8-(4-methoxy-phenyl)-1,3,6-trimethyl-8-phenyl-1,2,3,4,5,6,7,8-octahydro-pyrido[4,3-d]pyrimidine 
• 611-94-9 4-Methoxybenzophenone 
• 1138785-07-5 C₁₆H₁₆O₃ 
• 101018-39-7 α-ethenyl-α-phenyl-4-methoxybenzenemethanol 
• 5782-14-9 2-methyl-3-(4-methoxybenzene)-1H-indole 

Relevant academic research and scientific papers

PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.

The Neber route to substituted indoles

Two complementary procedures have been developed for the conversion of the oximes of α-aryl ketones to azirines. On heating, the azirines rearrange smoothly to the corresponding indoles. The overall transformation offers a versatile route to indoles, complementary to the Fischer indole synthesis. Copyright

α-Arylation of ketones by aryllead triacetates. Effect of methyl and phenyl substitution at the α position

An examination of the α-arylation of a number of ketones and their enolate salts by p-methoxyphenyllead triacetate provides further evidence for a very marked selectivity in the arylation reaction. It is found that the reaction proceeds well at tertiary α-carbons and at secondary centres activated by the presence of a phenyl group, but fails where the secondary centre is unactivated and at primary α-carbons.

General and efficient insertions of carbons carrying aryl and heteroaryl groups: Synthesis of α-Aryl- And α-heteroaryl-substituted ketones

Anions formed from the lithiation of a variety of 1-(arylmethyl)- and 1-(heteroarylmethyl)-benzotriazoles 1 with n-BuLi underwent addition to aliphatic and aromatic aldehydes and cyclic and acyclic ketones. Subsequent in situ thermal rearrangements of the intermediates in the presence of zinc bromide provided one-carbon chain-extended or ring-expanded α-aryl- and α-heteroaryl-substituted ketones 2 in moderate to excellent yields in simple one-pot operations with excellent regioselectivity in most cases. Substituent effects on the relative migration rates were investigated in the insertion reactions of 1-(4-methoxybenzyl)benzotriazole (1e) with XC6H4-COPh. The small and negative Hammett ρ+ value (-0.92) suggested that the rearrangements proceed via early, reagent-like, electron deficient transition states.