183172-57-8

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 5-forMyl-, phenylMethyl ester
• Synonyms: 1H-Pyrrole-2-carboxylic acid, 5-forMyl-, phenylMethyl ester
• CAS NO: 183172-57-8
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23134
• Mol File: 183172-57-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 5-forMyl-, phenylMethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 5-forMyl-, phenylMethyl ester(183172-57-8)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 5-forMyl-, phenylMethyl ester(183172-57-8)

Safety Data

• Hazardous Substances Data: 183172-57-8(Hazardous Substances Data)

Usage

Structure

A pyrrole ring with a formyl group at the 5-position and a phenylmethyl ester at the 2-position.

Derivative of pyrrole

Formyl derivative of pyrrole.

Biological activity

Potential antitumor and antiviral activities, has shown promising results in inhibiting the growth of cancer cells and in the treatment of viral infections, particularly as an inhibitor of the hepatitis C virus.

Application in organic electronic devices

Exhibits semiconducting properties.

Versatility

Potential applications in medicine, electronics, and materials science.

Upstream product

• 634-97-9 pyrrole-2-carboxyl acid 
• 100-39-0 benzyl bromide 
• 35889-87-3 1H-pyrrole-2-carboxylic acid benzyl ester 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 67858-55-3 benzyl 5-formyl-1-methyl-1H-pyrrole-2-carboxylate 
• 848352-99-8 5-(benzyloxycarbonyl)-1H-pyrrole-2-carboxylic acid 
• 185621-29-8 Benzyl 5-(hydroxymethylphenyl)pyrrole-2-carboxylate 

Relevant articles and documents

A facile and efficient multi-gram synthesis of N-protected 5-(guanidinocarbonyl)-1H-pyrrole-2-carboxylic acids

The synthesis of two versatile building blocks for supramolecular anion binding motifs, 5-(N-Boc-guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (1) and 5-(N-Cbz-guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (2) is reported. Using these building blocks, a guanidiniocarbonyl-pyrrole anion binding site can easily be introduced into more complex molecules by using standard amide coupling conditions. Both syntheses can be performed on a multi-gram scale. The products are obtained in pure form and can be stored as solids without decomposition. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Aryl ring rotation in porphyrins. A carbon-13 NMR spin-lattice relaxation time study

Overall tumbling and internal rotational motions in porphyrins bearing meso aryl substituents and, in some cases, flanking alkyl groups at the β-pyrrolic positions have been determined using 13C spin-lattice relaxation time measurements. In deuteriochloroform solution at 303 K, the overall reorientation of all three porphyrins investigated occurs with diffusion coefficients of ～1 × 109 s-1. In porphyrins with only hydrogen at the β-pyrrolic positions, the meso phenyl rings undergo rotations about their single bonds to the porphyrin with diffusion coefficients of ～4 × 109 s-1. Introduction of methyl substituents at the β-pyrrolic positions adjacent to the phenyl rings reduces these motions, but only to ～1 ×109 s-1. Thus, significant internal motions are present in both types of molecules. These motions occur on the time scale of many photoinduced electron and energy transfer processes in porphyrins covalently linked to electron or energy donors or acceptors through meso aryl groups. Thus, the internal librational motions may affect rates of photoinduced electron and energy transfer, even in relatively "rigid" molecular constructs.