183180-10-1

Upstream product

• 29182-97-6 N-methyl-2-bromoacetanilide 
• 183180-09-8 N-(2-benzyloxyphenyl)-2-(N-tert-butoxycarbonylamino)acetamide 
• 20012-63-9 o-(benzyloxy)aniline 
• 4530-20-5 BOC-glycine 

Downstream Products

• 1027932-21-3 methyl 2-[2-(N-(N-methyl-N-phenylcarbamoylmethyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)phenoxy]acetate 
• 205694-42-4 N-methyl-N-phenyl-2-(N-(2-benzyloxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide 
• 1027253-71-9 2-[2-(N-(N-methyl-N-phenylcarbamoylmethyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)phenoxy]acetic acid 
• 205694-43-5 N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide 
• 205694-41-3 N-methyl-N-phenyl-2-[N-(2-benzyloxyphenyl)-N-(2-aminoacetyl)amino]acetamide 

Relevant academic research and scientific papers

Aminophenol derivatives

Aminophenol derivatives represented by the following formula (1): STR1 wherein X is O or S; A is alkylene, R 1 is phenyl, etc., R 2 and R 3 are H or alkyl; R 4 is substituted carbamoylalkyl, etc.; R 5 is substituted amino, etc.; their salts, and optical i

Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors

A novel series of phenoxyacetic acid derivatives was synthesized based on considerations of the three-dimensional structural similarity of YM022 and RP72540. The gastrin/cholecystokinin (CCK)-B and CCK-A receptor antagonist activities of these compounds were evaluated by investigation of their affinities for human gastrin/CCK-B receptors and human CCK-A receptors, respectively. It was found that N-methyl-N-phenyl-2-[2-[N-(N-methyl-N- phenyl-carbamoylmethyl)-N-[2-[3-(3- methylphenyl)ureido]acetyl]amino]phenoxy]acetamide (20k, DZ-3514) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors.