183194-48-1

Basic information

• Product Name: Succinic acid mono-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3-yl] ester
• Synonyms: Succinic acid mono-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3-yl] ester
• CAS NO: 183194-48-1
• Molecular Weight: 752.821
• Mol File: 183194-48-1.mol

Chemical Properties

• CAS DataBase Reference: Succinic acid mono-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3-yl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: Succinic acid mono-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3-yl] ester(183194-48-1)
• EPA Substance Registry System: Succinic acid mono-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3-yl] ester(183194-48-1)

Safety Data

• Hazardous Substances Data: 183194-48-1(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 174463-02-6 N-(7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-isobutyramide 
• 193891-16-6 4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 174463-01-5 7-(2-Deoxy-β-D-erythropentofuranosyl)-5-methyl-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 90358-19-3 2-Amino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-5-methyl-7H-pyrrolo[2,3-d]pyrimidin 
• 90358-21-7 2-amino-7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-3,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-4-one 
• 90358-16-0 4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant articles and documents

Methylated DNA: The influence of 7-deaza-7-methylguanine on the structure and stability of oligonucleotides

The 7-deaza-2'-deoxy-7-methylguanosine (2b) [9], which is the glycosylic-bond-stable, noncharged analogue of 2'-deoxy-7-methylguanosine (1b), was incorporated in DNA by solid-phase synthesis. As building blocks, the protected phosphonate 3a and the phosphoramidite 3b were prepared. The 7- methyl group of 2b stabilizes the B-DNA duplex compared to 7-deaza-2'- deoxyguanosine but does not induce a B-Z transition as it is known from compound 1b. The stabilization by the 7-deaza-7-methylguanine moiety is sequence-dependent, and the nearest-neighbor influence is different from that of 7-deazaguanine. Homooligonucleotides of 2b show sigmoidal melting indicating a highly ordered single-stranded structure. In general, oligonucleotides containing 2b are very stable against hydrolysis with calf- spleen phosphodiesterase (CS-PDE, 5' 3' exonuclease), while phosphodiester hydrolysis with snake-venom phosphodiesterase (SV-PDE, 3'- 5'exonuclease) is only slightly reduced.