183207-70-7

Basic information

• Product Name: 1-N-BOC-3-CBZ-AMINO-PIPERIDINE
• Synonyms: 1-N-BOC-3-CBZ-AMINO-PIPERIDINE;3-Benzyloxycarbonylamino-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 3-(benzyloxycarbonylamino)piperidine-1-carboxylate
• CAS NO: 183207-70-7
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.413
• Mol File: 183207-70-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-N-BOC-3-CBZ-AMINO-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-3-CBZ-AMINO-PIPERIDINE(183207-70-7)
• EPA Substance Registry System: 1-N-BOC-3-CBZ-AMINO-PIPERIDINE(183207-70-7)

Safety Data

• Hazardous Substances Data: 183207-70-7(Hazardous Substances Data)

Usage

Molecular Class

Amines and piperidines

Molecular Structure

A derivative of piperidine with a BOC protecting group on the nitrogen atom and a CBZ protecting group on the 3-carbon atom

Molecular Weight

Not provided

Physical State

Not provided

Solubility

Not provided

Melting Point

Not provided

Boiling Point

Not provided

Functional Groups

BOC protecting group, CBZ protecting group, amine group

Reactivity

Versatile and reactive in chemical reactions

Uses

Commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules, important for the development of new drugs and potential therapeutic agents.

Upstream product

• 501-53-1 benzyl chloroformate 
• 144243-24-3 tert‐butyl 3‐aminopiperidine‐1‐carboxylate 
• 4129-17-3 diphenylphosphoranyl azide 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 

Downstream Products

• 1365161-09-6 (RS)-tert-butyl 3-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylate 
• 31648-54-1 (RS)-benzyl piperidin-3-ylcarbamate 
• 129888-62-6 N-(1-tert-butoxycarbonyl-3-piperidyl)acetamide 

Relevant articles and documents

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.