183281-91-6Relevant academic research and scientific papers
Studies on synthesis and structure of O-β-D- ribofuranosyl(1'→2')ribonucleosides and oligonucleotides
Markiewicz, Wojciech T.,Niewczyk, Anna,Gdaniec, Zofia,Adamiak, Dorota A.,Dauter, Zbigniew,Rypniewski, Wojciech,Chmielewski, Marcin
, p. 411 - 424 (2007/10/03)
Minor nucleosides found in several eukaryotic initiator tRNAs(i)(Met), O-β-D-ribofuranosyl(1'→2')adenosine and -guanosine (Ar and Gr), as well as their pyrimidine analogues, were obtained from N-protected 3',5'-O-(1,1,3,3- tetraisopropyldisiloxane-1,3-diyl)ribonucleosides and 1-O-acetyl-2,3,5-tri- O-benzoyl-β-D-ribofuranose in the presence of tin tetrachloride in 1,2- dichloroethane. A crystal structure has been solved for 2'-O-ribosyluridine. The 3'-phosphoramidites of protected 2'-O-ribosylribonucleosides were prepared as the reagents for 2'-O-ribofuranosyloligonucleotides synthesis. O- β-D-Ribofuranosyl(1'→2')adenylyl(3'→5')guanosine (ArpG) was obtained and its structure was analyzed by NMR spectroscopy.
An efficient synthesis and physico-chemical properties of 2′-O-D-ribofuranosylnucleosides, minor tRNA components
Mikhailov, Sergey N.,Efimtseva, Ekaterina V.,Gurskaya, Galina V.,Fomitcheva, Marina V.,Meshkov, Sergey V.,Zavodnik, Valery E.,De Bruyn, Andre,Janssen, Gerard,Rozenski, Jef,Herdewijn, Piet
, p. 75 - 92 (2007/10/03)
A high yield preparation of 9-(2-O-β-D-ribofuranosyl-β-D-ribofuranosyl)adenine, guanine- and the pyrimidine analogs (cytosine, thymine and uracil base moiety) has been achieved, and the conformational properties of the ring systems were investigated using NMR spectroscopy and X-ray.
Synthesis of Disaccharide Nucleosides and Their Incorporation into Oligonucleotides
Efimtseva, Ekaterina V.,Ermolinsky, Boris S.,Fomitcheva, Marina V.,Meshkov, Sergei V.,Padyukova, Nelly Sh.,et al.
, p. S206 - S209 (2007/10/03)
A high yield synthesis of 2'-O-ribofuranosyl nucleosides has been achieved and incorporation of the cytosine analogue into oligonucleotides was accomplished without difficulties.The supplementary cis diol group thus present in the middle of an oligonucleotide could be easily converted to a reactive dialdehyde moiety.
