183293-42-7

Upstream product

• 84341-89-9 (2S)-(+)-2-methyl-3-(toluene-4-sulfonyloxy)propionic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 183565-25-5 (R)-4-Benzyl-3-[(2R,3S,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentanoyl]-oxazolidin-2-one 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 183293-41-6 (S)-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal 

Downstream Products

• 216493-92-4 (2R,3S,4S,6R)-3-(4-Methoxy-benzyloxy)-2,4,6-trimethyl-7-triisopropylsilanyloxy-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 216493-93-5 (2R,3S,4S,6R)-3-(4-Methoxy-benzyloxy)-2,4,6-trimethyl-7-oxo-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 216493-97-9 (2R,3S,4S,6R)-7-Hydroxy-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 183293-44-9 Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester 
• 918961-62-3 Triisopropyl-{(2R,4S)-4-[(2R,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-silane 
• 918961-63-4 (2S,3S,4S,6R)-3-(4-methoxybenzyloxy)-2,4,6,-trimethyl-7-(triisopropylsilyloxy)heptan-1-ol 
• 183293-43-8 Toluene-4-sulfonic acid (2S,3R,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentyl ester 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 124755-30-2 (2R,4S)-4-[(2'R,4'S,5'S)-2'-(4-methoxyphenyl)-5'-methyl-1',3'-dioxan-4-yl]-2-methylpentan-1-ol 

Relevant academic research and scientific papers

Total synthesis of 10-deoxymethynolide, the aglycon of the macrolide antibiotic 10-deoxymethymycin

A short efficient total synthesis of 10-deoxymethynolide (2c), the aglycon of 10-deoxymethymycin (1c), has been accomplished in 16 steps and 12% overall yield from (S)-3-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal (15c). The synthesis features an expeditious preparation of (+)-5a, a synthetic equivalent of the Prelog-Djerassi lactonic acid, and the construction of a 12-membered lactone through an intramolecular Nozaki- Hiyama-Kishi coupling reaction.