124755-30-2

Upstream product

• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 124819-04-1 (2S,3S,4S,6R)-2,4,6-trimethylheptane-1,3,7-triol 
• 183293-42-7 Toluene-4-sulfonic acid (2S,3S,4R)-5-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-2,4-dimethyl-5-oxo-pentyl ester 
• 183506-80-1 (4R,2'R,3'S,4'S)-4-benzyl-3-(5'-benzyloxy-3'-hydroxy-2',4'-dimethylpentanoyl)-2-oxazolidinone 
• 183293-44-9 Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester 
• 183565-25-5 (R)-4-Benzyl-3-[(2R,3S,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentanoyl]-oxazolidin-2-one 
• 183293-43-8 Toluene-4-sulfonic acid (2S,3R,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentyl ester 
• 183506-81-2 (2S,3S,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentane-1,3-diol 
• 183293-40-5 (2S,3S,4S)-1-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentan-3-ol 
• 71828-89-2 (3R,5S,6S)-6-{(1S)-2-[(tert-butyldimethylsilyl)oxy]-1-methylethyl}-3,5-dimethyltetrahydro-2H-pyran-2-one 
• 108393-28-8 (2S,3R,4S)-5-benzyloxy-2,3-dimethylpentane-1,4-diol 

Downstream Products

• 918961-62-3 Triisopropyl-{(2R,4S)-4-[(2R,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-silane 
• 124755-31-3 (2S,3S,4S,6R)-1,3-(benzylidenedioxy)-7-<(p-methoxybenzyl)oxy>-2,4,6-trimethylheptane 
• 124755-32-4 (2S,3S,4S,6R)-3-(benzyloxy)-7-<(p-methoxybenzyl)oxy>-2,4,6-trimethyl-1-heptanol 
• 216493-92-4 (2R,3S,4S,6R)-3-(4-Methoxy-benzyloxy)-2,4,6-trimethyl-7-triisopropylsilanyloxy-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 216493-93-5 (2R,3S,4S,6R)-3-(4-Methoxy-benzyloxy)-2,4,6-trimethyl-7-oxo-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 216493-97-9 (2R,3S,4S,6R)-7-Hydroxy-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 918961-63-4 (2S,3S,4S,6R)-3-(4-methoxybenzyloxy)-2,4,6,-trimethyl-7-(triisopropylsilyloxy)heptan-1-ol 
• 124755-29-9 (2S,3S,4S,6R)-1,3-(benzylidenedioxy)-2,4,5-trimethyl-heptan-7-ol 

Relevant academic research and scientific papers

Total synthesis of 10-deoxymethynolide, the aglycon of the macrolide antibiotic 10-deoxymethymycin

A short efficient total synthesis of 10-deoxymethynolide (2c), the aglycon of 10-deoxymethymycin (1c), has been accomplished in 16 steps and 12% overall yield from (S)-3-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal (15c). The synthesis features an expeditious preparation of (+)-5a, a synthetic equivalent of the Prelog-Djerassi lactonic acid, and the construction of a 12-membered lactone through an intramolecular Nozaki- Hiyama-Kishi coupling reaction.

Synthesis of Polypropionate Subunits by SN2'Addition of Cuprates to Nonracemic Acyclic Vinyloxiranes

Synthetic sequences have been devised for conversion of the chiral pool ester 1 to differentially protected polypropionate subunit polyols 11, 13, 18, and 20.The following stereochemically significant steps were employed: (1) reagent directed Sharpless ep