183565-25-5

Upstream product

• 104701-87-3 (2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 112057-64-4 (R)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 93454-85-4 (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropionic acid methyl ester 

Downstream Products

• 183293-42-7 Toluene-4-sulfonic acid (2S,3S,4R)-5-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-2,4-dimethyl-5-oxo-pentyl ester 
• 216493-92-4 (2R,3S,4S,6R)-3-(4-Methoxy-benzyloxy)-2,4,6-trimethyl-7-triisopropylsilanyloxy-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 216493-93-5 (2R,3S,4S,6R)-3-(4-Methoxy-benzyloxy)-2,4,6-trimethyl-7-oxo-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 216493-97-9 (2R,3S,4S,6R)-7-Hydroxy-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptanoic acid (E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyl ester 
• 183293-44-9 Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester 
• 918961-62-3 Triisopropyl-{(2R,4S)-4-[(2R,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-silane 
• 918961-63-4 (2S,3S,4S,6R)-3-(4-methoxybenzyloxy)-2,4,6,-trimethyl-7-(triisopropylsilyloxy)heptan-1-ol 
• 183293-43-8 Toluene-4-sulfonic acid (2S,3R,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentyl ester 
• 124755-30-2 (2R,4S)-4-[(2'R,4'S,5'S)-2'-(4-methoxyphenyl)-5'-methyl-1',3'-dioxan-4-yl]-2-methylpentan-1-ol 

Relevant academic research and scientific papers

Synthesis and Configuration of a p-Aminoacetophenonic Acid Isolated from Endophyte of the Mangrove Plant Kandel candel

Two diastereomers of the title compound were synthesized through an enantioselective route, with the stereogenic center at the C-2 derived from a commercially available reagent and the one at the C-4 installed via Evans asymmetric aldol condensation. By comparison of 1H and 13C NMR spectra as well as optical rotation, the configuration of the natural product was as assigned as (-2R,4R). Some interesting issues such as suppression of the undesired yet dominating formation of cyclic ethers associated with deprotection of a TBS protected terminal hydroxyl group and the previously unknown differences in 1H NMR and IR between the end product separated by normal phase chromatography and that by reverse phase chromatography are also presented.

Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation

(Matrix Presented) Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.