183295-19-4

Upstream product

• 21090-30-2 3'-O-acetylthymidine 
• 183295-17-2 5'-O-dimethoxytrityl-thymidine-3'-O-(2-seleno-1,3,2-dithiaphospholane) 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 74-88-4 methyl iodide 

Downstream Products

• 151852-35-6 C₄₄H₄₉N₄O₁₄PS 

Relevant academic research and scientific papers

Synthesis and Reactivity of Dithymidyl-3',5''-phosphorothiofluoridates

Based upon dithiaphospholane method the new approach to the synthesis of dithymidine-3',5''-phosphorothioselenoate (mixture of two P-diastereomers) was established.Methylation of these compounds occurred exclusively at selenium atom and obtained methylselenyl esters under treatment with fluoride ion gave dithymidine-3',5''-phosphorothiofluoridates as the mixtures of both P-stereoisomers.Their base-catalyzed hydrolysis and methanolysis led to dithymidine-3',5''-phosphorothioates and thymidine-3',5''-(O-methyl)phosphorothioates, respectively.