18330-76-2

Basic information

• Product Name: 2-AMinobenzothiazole-6-carboxylic Acid Hydrochloride
• Synonyms: 6-Benzothiazolecarboxylic acid, 2-aMino-, Monohydrochloride;2-Amino-6-benzothiazolecarboxylic acid monohydrochloride;2-Amino-6-carboxybenzothiazolehydrochloride
• CAS NO: 18330-76-2
• Molecular Formula: C8H7ClN2O2S
• Molecular Weight: 230.67138
• Mol File: 18330-76-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMinobenzothiazole-6-carboxylic Acid Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMinobenzothiazole-6-carboxylic Acid Hydrochloride(18330-76-2)
• EPA Substance Registry System: 2-AMinobenzothiazole-6-carboxylic Acid Hydrochloride(18330-76-2)

Safety Data

• Hazardous Substances Data: 18330-76-2(Hazardous Substances Data)

Usage

General Description

2-Aminobenzothiazole-6-carboxylic Acid Hydrochloride is a chemical compound with the formula C9H8N2O2S·HCl. It is a hydrochloride salt of the amino acid derivative 2-aminobenzothiazole-6-carboxylic acid. 2-AMinobenzothiazole-6-carboxylic Acid Hydrochloride has been investigated for its potential use in pharmaceutical research, particularly in the development of new drugs and treatments. It may also have applications in other fields, such as organic synthesis and material science. Additionally, this compound is notable for its unique structure and potential biological activity, making it a subject of interest for further study and exploration.

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 540-72-7 sodium thiocyanide 
• 333-20-0 potassium thioacyanate 
• 94-09-7 p-aminoethylbenzoate 
• 18330-64-8 4-amino-3-thiocyanatobenzoic acid 
• 50850-93-6 ethyl 2-aminobenzothiazole-6-carboxylate 

Relevant articles and documents

Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents

Oxidative stress is the product or aetiology of various multifactorial diseases; on the other hand, the development of multifunctional compounds is a recognized strategy for the control of complex diseases. To this end, a series of benzothiazole derivatives was synthesized and evaluated for their multifunctional effectiveness as antioxidant, sunscreen (filter), antifungal and antiproliferative agents. Compounds were easily synthesized via condensation reaction between 2-aminothiophenols and different benzaldehydes. SAR study, particularly in position 2 and 6 of benzothiazoles, led to the identification of 4g and 4k as very interesting potential compounds for the design of multifunctional drugs. In particular, compound 4g is the best blocker of hERG potassium channels expressed in HEK 293 cells exhibiting 60.32percent inhibition with IC50 = 4.79 μM.

Synthesis and evaluation of18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in alzheimer's disease

Imaging agents targeting amyloid β(Aβ) may be useful for early diagnosis and follow-up of treatment of patients with Alzheimer's disease (AD). Three of five tested 2-(4′-fluorophenyl)-1,3-benzothiazoles displayed high binding affinities for Aβ plaques in

Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library

An inhibitor of the complex of factor VIIa and tissue factor (fVIIa/TF), 2-substituted-4-amidinophenylpyruvic acid 1a, was structurally modified with the aim of increasing its potency and selectivity. The lead compound 1a was originally found in our factor Xa (fXa) inhibitor library on the basis of structural similarity of the primary binding sites of fVIIa and fXa. The design was based on computational docking studies using the extracted active site of fVIIa. Compound 1j was found to inhibit factor VIIa/TF at nanomolar concentration with improved selectivity versus fXa and thrombin and it preferentially prolonged the clotting time in the TF-dependent extrinsic pathway.